Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inoue

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalJournal of Pharmacological Sciences
Volume126
Issue number2
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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