Interleukin-1β enhances susceptibility to hyperthermia-induced seizures in developing rats

Mitsumasa Fukuda, Yuka Suzuki, Yoshito Ishizaki, Ryutaro Kira, Chiya Kikuchi, Shohei Watanabe, Hitomi Hino, Takehiko Morimoto, Toshiro Hara, Eiichi Ishii

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Abstract

Cytokines have been shown to influence susceptibility to febrile seizures and epilepsy. In this study, the role of interleukin-1β (IL-1β) was examined in developing rats. IL-1β and interleukin-1 receptor antagonist (IL-1ra) were administered to developing rats, and seizures were induced by moist warm air. Twenty male Lewis rats (21-23 days old) were divided into two groups (IL-1β and saline control groups) and two holes were made in the skull for EEG electrodes. We applied human recombinant IL-1β intra-nasally 1 h before seizures induced by moist warm air. The brain temperature at the appearance of seizure discharges on EEG, and the latency time from the hyperthermia onset until the appearance of seizure discharges on EEG were measured. And the same study using IL-1ra was performed. The median brain temperature for the IL-1β group, 42.6 °C (range: 41.8-43.0), was significantly lower than that for the control, 42.9 (42.3-43.4) (P = 0.043). The brain temperature for the IL-1ra group, 43.3 (42.8-43.7), was significantly higher than that for the control, 42.9 (42.2-43.5) (P = 0.011), and the latency time for the IL-1ra group, 398 s (270-561), was significantly longer than that for the control, 325 (252-462) (P = 0.035). These results demonstrate that IL-1β promotes hyperthermia-induced seizures in developing rats.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalSeizure
Volume18
Issue number3
DOIs
Publication statusPublished - Apr 1 2009

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Induced Hyperthermia
Interleukin-1
Seizures
Interleukin-1 Receptors
Electroencephalography
Temperature
Brain
Air
Febrile Seizures
Skull
Epilepsy
Electrodes
Fever
Cytokines
Control Groups

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Fukuda, M., Suzuki, Y., Ishizaki, Y., Kira, R., Kikuchi, C., Watanabe, S., ... Ishii, E. (2009). Interleukin-1β enhances susceptibility to hyperthermia-induced seizures in developing rats. Seizure, 18(3), 211-214. https://doi.org/10.1016/j.seizure.2008.10.001

Interleukin-1β enhances susceptibility to hyperthermia-induced seizures in developing rats. / Fukuda, Mitsumasa; Suzuki, Yuka; Ishizaki, Yoshito; Kira, Ryutaro; Kikuchi, Chiya; Watanabe, Shohei; Hino, Hitomi; Morimoto, Takehiko; Hara, Toshiro; Ishii, Eiichi.

In: Seizure, Vol. 18, No. 3, 01.04.2009, p. 211-214.

Research output: Contribution to journalArticle

Fukuda, M, Suzuki, Y, Ishizaki, Y, Kira, R, Kikuchi, C, Watanabe, S, Hino, H, Morimoto, T, Hara, T & Ishii, E 2009, 'Interleukin-1β enhances susceptibility to hyperthermia-induced seizures in developing rats', Seizure, vol. 18, no. 3, pp. 211-214. https://doi.org/10.1016/j.seizure.2008.10.001
Fukuda M, Suzuki Y, Ishizaki Y, Kira R, Kikuchi C, Watanabe S et al. Interleukin-1β enhances susceptibility to hyperthermia-induced seizures in developing rats. Seizure. 2009 Apr 1;18(3):211-214. https://doi.org/10.1016/j.seizure.2008.10.001
Fukuda, Mitsumasa ; Suzuki, Yuka ; Ishizaki, Yoshito ; Kira, Ryutaro ; Kikuchi, Chiya ; Watanabe, Shohei ; Hino, Hitomi ; Morimoto, Takehiko ; Hara, Toshiro ; Ishii, Eiichi. / Interleukin-1β enhances susceptibility to hyperthermia-induced seizures in developing rats. In: Seizure. 2009 ; Vol. 18, No. 3. pp. 211-214.
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