Interleukin-1 but not tumour necrosis factor α synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells

Masutaka Furue, C. H. Chang, K. Tamaki

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28 Citations (Scopus)

Abstract

Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B 7/BB7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor α (TNF-α) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-α. In this paper, we present that IL-1, but not TNF-α, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalBritish Journal of Dermatology
Volume135
Issue number2
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

Langerhans Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Up-Regulation
Tumor Necrosis Factor-alpha
Macrophage Colony-Stimulating Factor
B7 Antigens
Antigens
Keratinocytes
Cytokines

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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title = "Interleukin-1 but not tumour necrosis factor α synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells",
abstract = "Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B 7/BB7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor α (TNF-α) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-α. In this paper, we present that IL-1, but not TNF-α, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC.",
author = "Masutaka Furue and Chang, {C. H.} and K. Tamaki",
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AU - Furue, Masutaka

AU - Chang, C. H.

AU - Tamaki, K.

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N2 - Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B 7/BB7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor α (TNF-α) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-α. In this paper, we present that IL-1, but not TNF-α, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC.

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