Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B 7/BB7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor α (TNF-α) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-α. In this paper, we present that IL-1, but not TNF-α, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC.
|Number of pages||5|
|Journal||British Journal of Dermatology|
|Publication status||Published - 1996|
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