Interleukin-15 as an immune adjuvant to increase the efficacy of Mycobacterium bovis bacillus Calmette-Guérin vaccination

Masayuki Umemura, Hitoshi Nishimura, Kimika Saito, Toshiki Yajima, Goro Matsuzaki, Satoru Mizuno, Isamu Sugawara, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)

    Abstract

    Interleukin-15 (IL-15) transgenic mice which had been inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) 24 weeks previously showed resistance against airborne infection with Mycobacterium tuberculosis H37Rv accompanied by an increased CD8+-Tcl-cell response. IL-15 may be used as an immune adjuvant given with BCG vaccination to enhance its biologic efficacy.

    Original languageEnglish
    Pages (from-to)6045-6048
    Number of pages4
    JournalInfection and Immunity
    Volume71
    Issue number10
    DOIs
    Publication statusPublished - Oct 1 2003

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases

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