Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury

Risa Nakamura, Naoyoshi Maeda, Kensuke Shibata, Hisakata Yamada, Tetsuo Kase, Yasunobu Yoshikai

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Highly pathogenic influenza A viruses cause acute severe pneumonia to which the occurrence of "cytokine storm" has been proposed to contribute. Here we show that interleukin-15 (IL-15) knockout (KO) mice exhibited reduced mortality after infection with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) albeit the viral titers of these mice showed no difference from those of control mice. There were significantly fewer antigen-specific] CD44+ CD8+ T cells in the lungs of infected IL-15 KO mice, and adoptive transfer of the CD8+ T cells caused reduced survival of IL-15 KO mice following influenza virus infection. Mice deficient in β2-microglobulin by gene targeting and those depleted of CD8+ T cells by in vivo administration of anti-CD8 monoclonal antibody displayed a reduced mortality rate after infection. These results indicate that IL-15-dependent CD8 + T cells are at least partly responsible for the pathogenesis of acute pneumonia caused by influenza A virus.

Original languageEnglish
Pages (from-to)5574-5582
Number of pages9
JournalJournal of virology
Volume84
Issue number11
DOIs
Publication statusPublished - Jun 2010

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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