Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice

Kyoko Inagaki-Ohara, Hitoshi Nishimura, Akio Mitani, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    127 Citations (Scopus)

    Abstract

    Several cytokines including stem cell factor (SCF) and interleukin (IL)-7 are known to be required for development of γδ T cell receptor (TCR) intestinal intraepithelial lymphocytes (i-IEL) in mice. We show here the effects of IL-15 on the proliferation and maintenance of murine γδ i-IEL in vitro. γδ i-IEL constitutively expressed a high level of Il-15 receptor cc mRNA and proliferated in response to IL-15 more vigorously than αβ i-IEL. Vγ/δ repertoire analysis revealed that IL-15, like IL-2, induced polyclonal expansion of γδ i-IEL, whereas γδ i-IEL responding to IL-7 showed a Vγ/δ repertoire skewed towards Vγ1/Vδ4, Vδ5. IL-15 efficiently prevented γδ i-IEL from apoptosis induced by growth factor deprivation. This rescue was accompanied by up-regulation of Bcl-2 expression. These results suggest that IL-15 plays important roles in proliferation and maintenance of γδ i-IEL.

    Original languageEnglish
    Pages (from-to)2885-2891
    Number of pages7
    JournalEuropean Journal of Immunology
    Volume27
    Issue number11
    DOIs
    Publication statusPublished - Nov 1 1997

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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