Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice

A. Mitani, H. Nishimura, K. Hirose, J. Washizu, Y. Kimura, S. Tanaka, G. Yamamoto, T. Noguchi, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

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    Abstract

    We previously reported that exogenous interleukin-15 (IL-15) induces proliferation and activation of intestinal intraepithelial lymphocytes (i- IEL) in naive mice. To investigate the ability of endogenous IL-15 to stimulate i-IEL in vivo, we monitored i-IEL and intestinal epithelial cells (i-EC) in mice after an oral infection with Listeria monocytogenes. Although the populations of αβ and γδ i-IEL were not significantly changed after the oral infection, the expression level of interferon-γ (IFN-γ) was increased both at transcriptional and protein levels, and a conversely marked decrease in interleukin-4 (IL-4) was detected in the i-IEL on day 1 after infection as compared with before infection. The T helper 1 (Th1)-biased response of i-IEL coincided with a peak response of IL-15 production in the i-EC after oral infection. These results suggested that IL-15 produced from i-EC may be at least partly involved in the stimulation of i-IEL to produce IFN-γ after oral infection with L. monocytogenes.

    Original languageEnglish
    Pages (from-to)92-99
    Number of pages8
    JournalImmunology
    Volume97
    Issue number1
    DOIs
    Publication statusPublished - Jan 1 1999

    Fingerprint

    Oral Stage
    Interleukin-15
    Listeria monocytogenes
    Infection
    Epithelial Cells
    Interferons
    Aptitude
    Interleukin-4
    Lymphocytes

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Mitani, A., Nishimura, H., Hirose, K., Washizu, J., Kimura, Y., Tanaka, S., ... Yoshikai, Y. (1999). Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice. Immunology, 97(1), 92-99. https://doi.org/10.1046/j.1365-2567.1999.00752.x

    Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice. / Mitani, A.; Nishimura, H.; Hirose, K.; Washizu, J.; Kimura, Y.; Tanaka, S.; Yamamoto, G.; Noguchi, T.; Yoshikai, Yasunobu.

    In: Immunology, Vol. 97, No. 1, 01.01.1999, p. 92-99.

    Research output: Contribution to journalArticle

    Mitani, A, Nishimura, H, Hirose, K, Washizu, J, Kimura, Y, Tanaka, S, Yamamoto, G, Noguchi, T & Yoshikai, Y 1999, 'Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice', Immunology, vol. 97, no. 1, pp. 92-99. https://doi.org/10.1046/j.1365-2567.1999.00752.x
    Mitani, A. ; Nishimura, H. ; Hirose, K. ; Washizu, J. ; Kimura, Y. ; Tanaka, S. ; Yamamoto, G. ; Noguchi, T. ; Yoshikai, Yasunobu. / Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice. In: Immunology. 1999 ; Vol. 97, No. 1. pp. 92-99.
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