Interleukin-15 selectively expands CD57+CD28-CD4+ T cells, which are increased in active rheumatoid arthritis

Hisakata Yamada, Nobutaka Kaibara, Shinji Okano, Takeshi Maeda, Toshihide Shuto, Yasuharu Nakashima, Ken Okazaki, Yukihide Iwamoto

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Proinflammatory cytokines as well as CD4+ T cells play critical roles in the pathogenesis of rheumatoid arthritis (RA). Recently, an increase of CD57+ or CD28-CD4+ T cells was demonstrated in RA, although the mechanism of the increase of these T cells is unclear. In this study, we first examined the relationship between CD57+CD4+ T cells and CD28-CD4+ T cells and found CD57+CD28-CD4+ T cells, but neither CD57+CD28+ nor CD57-CD28+ cells, expanded in the peripheral blood of active RA. In vitro experiments revealed that CD57+CD28-CD4+ T cells selectively expanded in response to IL-15. Furthermore IL-15-stimulated CD57+CD28-CD4+ T cells induced TNF-α production from monocytes. These results suggest that CD57+CD28-CD4+ T cells are involved in the pathogenesis of RA by responding to IL-15.

Original languageEnglish
Pages (from-to)328-335
Number of pages8
JournalClinical Immunology
Issue number3
Publication statusPublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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