Interleukin-18 in human milk

Yasushi Takahata, Hidetoshi Takada, Akihiko Nomura, Koichi Ohshima, Hideki Nakayama, Tomoteru Tsuda, Hitoo Nakano, Toshiro Hara

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Abstract

We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively). There was a significant correlation between the levels of IL-18 and soluble Fas ligand in colostrum (p = 0.0003). IL-18 was detected in actively secreting epithelial cells in lactating mammary gland by immunohistochemical staining. These results suggest that IL-18 in colostrum plays an important role in host defense of high-risk neonates.

Original languageEnglish
Pages (from-to)268-272
Number of pages5
JournalPediatric Research
Volume50
Issue number2
DOIs
Publication statusPublished - Jan 1 2001

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Takahata, Y., Takada, H., Nomura, A., Ohshima, K., Nakayama, H., Tsuda, T., ... Hara, T. (2001). Interleukin-18 in human milk. Pediatric Research, 50(2), 268-272. https://doi.org/10.1203/00006450-200108000-00017