Interleukin-18 in human milk

Yasushi Takahata; Hidetoshi Takada; Akihiko Nomura; Koichi Ohshima; Hideki Nakayama; Tomoteru Tsuda; Hitoo Nakano; Toshiro Hara

doi:10.1203/00006450-200108000-00017

Interleukin-18 in human milk

Yasushi Takahata, Hidetoshi Takada, Akihiko Nomura, Koichi Ohshima, Hideki Nakayama, Tomoteru Tsuda, Hitoo Nakano, Toshiro Hara

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively). There was a significant correlation between the levels of IL-18 and soluble Fas ligand in colostrum (p = 0.0003). IL-18 was detected in actively secreting epithelial cells in lactating mammary gland by immunohistochemical staining. These results suggest that IL-18 in colostrum plays an important role in host defense of high-risk neonates.

Original language	English
Pages (from-to)	268-272
Number of pages	5
Journal	Pediatric Research
Volume	50
Issue number	2
DOIs	https://doi.org/10.1203/00006450-200108000-00017
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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title = "Interleukin-18 in human milk",

abstract = "We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively). There was a significant correlation between the levels of IL-18 and soluble Fas ligand in colostrum (p = 0.0003). IL-18 was detected in actively secreting epithelial cells in lactating mammary gland by immunohistochemical staining. These results suggest that IL-18 in colostrum plays an important role in host defense of high-risk neonates.",

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T1 - Interleukin-18 in human milk

AU - Takahata, Yasushi

AU - Takada, Hidetoshi

AU - Nomura, Akihiko

AU - Ohshima, Koichi

AU - Nakayama, Hideki

AU - Tsuda, Tomoteru

AU - Nakano, Hitoo

AU - Hara, Toshiro

PY - 2001

Y1 - 2001

N2 - We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively). There was a significant correlation between the levels of IL-18 and soluble Fas ligand in colostrum (p = 0.0003). IL-18 was detected in actively secreting epithelial cells in lactating mammary gland by immunohistochemical staining. These results suggest that IL-18 in colostrum plays an important role in host defense of high-risk neonates.

AB - We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively). There was a significant correlation between the levels of IL-18 and soluble Fas ligand in colostrum (p = 0.0003). IL-18 was detected in actively secreting epithelial cells in lactating mammary gland by immunohistochemical staining. These results suggest that IL-18 in colostrum plays an important role in host defense of high-risk neonates.

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VL - 50

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JO - Pediatric Research

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Interleukin-18 in human milk

Abstract

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