Interleukin-4 in chronic myelomonocytic leukemia: Growth suppression of hematopoietic precursors in the chronic phase and stimulation in the acute phase

K. Yanagisawa, K. Kishimoto, Takahiko Horiuchi, K. Takada, M. Yasukawa, S. Fujita

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Abstract

We examined the effects of interleukin-4 (IL-4) on the growth of hematopoietic precursors from a patient with chronic myelomonocytic leukemia (CMMoL). In the chronic phase of the disease, IL-4 inhibited spontaneous colony formation by CMMoL cells in semi-solid culture. However, in the acute phase, IL-4 promoted colony formation. These effects of IL-4 were abolished completely by the addition of anti-IL-4 neutralizing antibodies. The spontaneous colony formation by CMMoL cells in both the chronic and acute phases was inhibited by the addition of anti-IL-6 antibodies. On the other hand, neither anti-IL-6, anti-granulocyte macrophage colony-stimulating factor (GMCSF), anti-IL-1β nor anti-tumor necrosis factor α (TNFα) antibodies inhibited IL-4-induced colony formation by CMMoL cells in the acute phase. IL-4 suppressed the production of IL-6 by CMMoL cells in both the chronic and acute phases. These results suggest that in the present patient, IL-4 suppressed the IL-6-mediated autocrine growth of CMMoL cells in both the chronic and acute phases, but directly stimulated their growth in the acute phase.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalActa Haematologica
Volume92
Issue number2
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Hematology

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