Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients

Ataru Taniguchi, Mitsuo Fukushima, Michihiro Ohya, Yoshikatsu Nakai, Satoru Yoshii, Shoichiro Nagasaka, Kazunari Matsumoto, Yoshiro Taki, Akira Kuroe, Fusanori Nishimura, Yutaka Seino

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Abstract

The aim of the present study was to investigate the relationships between interleukin 6 (IL-6) and insulin resistance, serum leptin, serum adiponectin, or serum lipids including triglycerides in 98 nonobese Japanese type 2 diabetic patients. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Serum IL-6 concentration was negatively correlated to high-density lipoprotein cholesterol (r = -0.295, P = .004), but was not associated with HOMA-IR (r = 0.016, P = .871), body mass index (BMI) (r = 0.090, P = .375), systolic (r = 0.169, P = .116) and diastolic (r = -0.061, P = .570) blood pressures, leptin (r = 0.062, P = .544), and adiponectin (r = -0.020, P = .841) in these patients. In contrast, serum leptin level was positively correlated to HOMA-IR (r = 0.291, P = .004), BMI (r = 0.338, P < .001), and systolic blood pressure (r = 0.241, P = .025). Serum adiponectin level was negatively correlated to HOMA-IR (r = -0.288, P = .005), BMI (r = -0.308, P = .002), diastolic blood pressure (r = -0.269, P = .012), and triglycerides (r = -0.338, P < .001), and positively correlated to high-density lipoprotein cholesterol (r = 0.300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients.

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume55
Issue number2
DOIs
Publication statusPublished - Feb 1 2006

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Adiponectin
Leptin
Insulin Resistance
Interleukin-6
Serum
Blood Pressure
Body Mass Index
HDL Cholesterol
Triglycerides
Fasting
Homeostasis
Lipids

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. / Taniguchi, Ataru; Fukushima, Mitsuo; Ohya, Michihiro; Nakai, Yoshikatsu; Yoshii, Satoru; Nagasaka, Shoichiro; Matsumoto, Kazunari; Taki, Yoshiro; Kuroe, Akira; Nishimura, Fusanori; Seino, Yutaka.

In: Metabolism: Clinical and Experimental, Vol. 55, No. 2, 01.02.2006, p. 258-262.

Research output: Contribution to journalArticle

Taniguchi, A, Fukushima, M, Ohya, M, Nakai, Y, Yoshii, S, Nagasaka, S, Matsumoto, K, Taki, Y, Kuroe, A, Nishimura, F & Seino, Y 2006, 'Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients', Metabolism: Clinical and Experimental, vol. 55, no. 2, pp. 258-262. https://doi.org/10.1016/j.metabol.2005.08.020
Taniguchi, Ataru ; Fukushima, Mitsuo ; Ohya, Michihiro ; Nakai, Yoshikatsu ; Yoshii, Satoru ; Nagasaka, Shoichiro ; Matsumoto, Kazunari ; Taki, Yoshiro ; Kuroe, Akira ; Nishimura, Fusanori ; Seino, Yutaka. / Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. In: Metabolism: Clinical and Experimental. 2006 ; Vol. 55, No. 2. pp. 258-262.
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AU - Nagasaka, Shoichiro

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