Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

Jun Yatsunami; Nobuko Tsuruta; Kenichi Ogata; Kentaro Wakamatsu; Koichi Takayama; Masayuki Kawasaki; Yoichi Nakanishi; Nobuyuki Hara; Shin Ichiro Hayashi

doi:10.1016/S0304-3835(97)00296-6

Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

Jun Yatsunami, Nobuko Tsuruta, Kenichi Ogata, Kentaro Wakamatsu, Koichi Takayama, Masayuki Kawasaki, Yoichi Nakanishi, Nobuyuki Hara, Shin Ichiro Hayashi

Department of Respirology

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Cancer Letters
Volume	120
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(97)00296-6
Publication status	Published - Nov 25 1997

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00296-6

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title = "Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung",

abstract = "We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.",

author = "Jun Yatsunami and Nobuko Tsuruta and Kenichi Ogata and Kentaro Wakamatsu and Koichi Takayama and Masayuki Kawasaki and Yoichi Nakanishi and Nobuyuki Hara and Hayashi, {Shin Ichiro}",

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T1 - Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

AU - Yatsunami, Jun

AU - Tsuruta, Nobuko

AU - Ogata, Kenichi

AU - Wakamatsu, Kentaro

AU - Takayama, Koichi

AU - Kawasaki, Masayuki

AU - Nakanishi, Yoichi

AU - Hara, Nobuyuki

AU - Hayashi, Shin Ichiro

PY - 1997/11/25

Y1 - 1997/11/25

N2 - We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.

AB - We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.

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Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

Abstract

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UN SDGs

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