Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

Jun Yatsunami, Nobuko Tsuruta, Kenichi Ogata, Kentaro Wakamatsu, Koichi Takayama, Masayuki Kawasaki, Yoichi Nakanishi, Nobuyuki Hara, Shin Ichiro Hayashi

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Abstract

We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalCancer Letters
Volume120
Issue number1
DOIs
Publication statusPublished - Nov 25 1997

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Small Cell Lung Carcinoma
Interleukin-8
Cell Line
Large Cell Carcinoma
Neoplasms
Small Cell Carcinoma
Non-Small Cell Lung Carcinoma
Immune Sera
Squamous Cell Carcinoma
Lung Neoplasms
Adenocarcinoma
Staining and Labeling
Biopsy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yatsunami, J., Tsuruta, N., Ogata, K., Wakamatsu, K., Takayama, K., Kawasaki, M., ... Hayashi, S. I. (1997). Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung. Cancer Letters, 120(1), 101-108. https://doi.org/10.1016/S0304-3835(97)00296-6

Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung. / Yatsunami, Jun; Tsuruta, Nobuko; Ogata, Kenichi; Wakamatsu, Kentaro; Takayama, Koichi; Kawasaki, Masayuki; Nakanishi, Yoichi; Hara, Nobuyuki; Hayashi, Shin Ichiro.

In: Cancer Letters, Vol. 120, No. 1, 25.11.1997, p. 101-108.

Research output: Contribution to journalArticle

Yatsunami, J, Tsuruta, N, Ogata, K, Wakamatsu, K, Takayama, K, Kawasaki, M, Nakanishi, Y, Hara, N & Hayashi, SI 1997, 'Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung', Cancer Letters, vol. 120, no. 1, pp. 101-108. https://doi.org/10.1016/S0304-3835(97)00296-6
Yatsunami J, Tsuruta N, Ogata K, Wakamatsu K, Takayama K, Kawasaki M et al. Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung. Cancer Letters. 1997 Nov 25;120(1):101-108. https://doi.org/10.1016/S0304-3835(97)00296-6
Yatsunami, Jun ; Tsuruta, Nobuko ; Ogata, Kenichi ; Wakamatsu, Kentaro ; Takayama, Koichi ; Kawasaki, Masayuki ; Nakanishi, Yoichi ; Hara, Nobuyuki ; Hayashi, Shin Ichiro. / Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung. In: Cancer Letters. 1997 ; Vol. 120, No. 1. pp. 101-108.
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