Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung

Jun Yatsunami, Nobuko Tsuruta, Kenichi Ogata, Kentaro Wakamatsu, Koichi Takayama, Masayuki Kawasaki, Yoichi Nakanishi, Nobuyuki Hara, Shin Ichiro Hayashi

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76 Citations (Scopus)

Abstract

We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalCancer Letters
Volume120
Issue number1
DOIs
Publication statusPublished - Nov 25 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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