Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction

Satoru Chiba, Masanao Naya, Hiroyuki Iwano, Keiichiro Yoshinaga, Chietsugu Katoh, Osamu Manabe, Satoshi Yamada, Satoru Wakasa, Suguru Kubota, Yoshiro Matsui, Nagara Tamaki, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

Abstract

Purpose: Diastolic function is impaired in patients with end-stage heart failure. Favorable structural changes by surgical ventricular reconstruction (SVR) are thought to improve diastolic function, however, previous studies reported the contradictory results. We hypothesized that cardiac oxidative metabolism and diastolic dysfunction might improve in parallel to the reduction of left ventricular chamber size after SVR. Methods: We studied 11 patients underwent SVR associated with mitral valve repair for end-stage heart failure due to dilated cardiomyopathy. Diastolic function was assessed by echocardiography and myocardial oxidative metabolism was measured by the monoexponential clearance (k-mono) of 11C-acetate positron emission tomography at baseline and 1 month after SVR. Results: All patients had preoperative severe diastolic dysfunction [E/A 4.11 ± 1.18, deceleration time (DT) 134 ± 26 ms]. The study patients were divided into 2 groups according to the changes in diastolic function after SVR; unchanged or worsened diastolic function in 6 patients (55 %, Non-responder) and improved diastolic function in 5 (45 %, Responder). K-mono and wall stress decreased only in responder. The changes in k-mono before and after SVR correlated with those in deceleration time (r = -0.63; p < 0.05) and wall stress (r = 0.75; p < 0.01). Conclusions: Improvement of diastolic dysfunction in patients with end-stage heart failure by SVR was in parallel to that in oxidative metabolism. It suggests that SVR reduced excessive metabolism during the diastolic phase, in part, via the improvement in diastolic function and the reduction in LV wall stress.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume40
Issue number3
DOIs
Publication statusPublished - Feb 1 2013
Externally publishedYes

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Deceleration
Heart Failure
Dilated Cardiomyopathy
Mitral Valve
Positron-Emission Tomography
Echocardiography
carbon-11 acetate

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction. / Chiba, Satoru; Naya, Masanao; Iwano, Hiroyuki; Yoshinaga, Keiichiro; Katoh, Chietsugu; Manabe, Osamu; Yamada, Satoshi; Wakasa, Satoru; Kubota, Suguru; Matsui, Yoshiro; Tamaki, Nagara; Tsutsui, Hiroyuki.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 40, No. 3, 01.02.2013, p. 349-355.

Research output: Contribution to journalArticle

Chiba, Satoru ; Naya, Masanao ; Iwano, Hiroyuki ; Yoshinaga, Keiichiro ; Katoh, Chietsugu ; Manabe, Osamu ; Yamada, Satoshi ; Wakasa, Satoru ; Kubota, Suguru ; Matsui, Yoshiro ; Tamaki, Nagara ; Tsutsui, Hiroyuki. / Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction. In: European Journal of Nuclear Medicine and Molecular Imaging. 2013 ; Vol. 40, No. 3. pp. 349-355.
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AU - Chiba, Satoru

AU - Naya, Masanao

AU - Iwano, Hiroyuki

AU - Yoshinaga, Keiichiro

AU - Katoh, Chietsugu

AU - Manabe, Osamu

AU - Yamada, Satoshi

AU - Wakasa, Satoru

AU - Kubota, Suguru

AU - Matsui, Yoshiro

AU - Tamaki, Nagara

AU - Tsutsui, Hiroyuki

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N2 - Purpose: Diastolic function is impaired in patients with end-stage heart failure. Favorable structural changes by surgical ventricular reconstruction (SVR) are thought to improve diastolic function, however, previous studies reported the contradictory results. We hypothesized that cardiac oxidative metabolism and diastolic dysfunction might improve in parallel to the reduction of left ventricular chamber size after SVR. Methods: We studied 11 patients underwent SVR associated with mitral valve repair for end-stage heart failure due to dilated cardiomyopathy. Diastolic function was assessed by echocardiography and myocardial oxidative metabolism was measured by the monoexponential clearance (k-mono) of 11C-acetate positron emission tomography at baseline and 1 month after SVR. Results: All patients had preoperative severe diastolic dysfunction [E/A 4.11 ± 1.18, deceleration time (DT) 134 ± 26 ms]. The study patients were divided into 2 groups according to the changes in diastolic function after SVR; unchanged or worsened diastolic function in 6 patients (55 %, Non-responder) and improved diastolic function in 5 (45 %, Responder). K-mono and wall stress decreased only in responder. The changes in k-mono before and after SVR correlated with those in deceleration time (r = -0.63; p < 0.05) and wall stress (r = 0.75; p < 0.01). Conclusions: Improvement of diastolic dysfunction in patients with end-stage heart failure by SVR was in parallel to that in oxidative metabolism. It suggests that SVR reduced excessive metabolism during the diastolic phase, in part, via the improvement in diastolic function and the reduction in LV wall stress.

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