Intervention of isomaltodextrin mitigates intestinal inflammation in a dextran sodium sulfate-induced mouse model of colitis via inhibition of toll-like receptor-4

Kaustav Majumder, Toshihiko Fukuda, Hua Zhang, Takeo Sakurai, Yoshifumi Taniguchi, Hikaru Watanabe, Hitoshi Mitsuzumi, Toshiro Matsui, Yoshinori Mine

Research output: Contribution to journalArticle

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Abstract

Isomaltodextrin (IMD), a highly branched α-glucan, is a type of resistant starch. Earlier studies have indicated that polysaccharides could prevent inflammation and can be effective in reducing the complications of chronic gastrointestinal diseases such as inflammatory bowel disease (IBD). Therefore, the aim of the present study was to evaluate the anti-inflammatory effect of IMD in dextran sodium sulfate (DSS)-induced colitis in a mouse model. IMD (0.5, 1.0, 2.5, and 5.0% (w/v)) was given orally for 23 days to female Balb/c mice, and then 5% DSS was administered to induce colitis (from day 15 onward to the end of the trial). IMD could not prevent DSS-induced weight loss or colon shortening. However, IMD could reduce inflammatory cytokines, TNF-α and IL-6, in the colon. Gene expression indicated the tendency of IMD to suppress pro-inflammatory cytokines IL-1β, MCP-1, and IL-17 and to increase an anti-inflammatory cytokine, IL-10. Further study revealed that the antiinflammatory action of IMD mediates through inhibition of the expression of Toll-like receptor-4.

Original languageEnglish
Pages (from-to)810-817
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number4
DOIs
Publication statusPublished - Feb 1 2017

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Dextran Sulfate
Toll-Like Receptor 4
sodium sulfate
colitis
dextran
Colitis
cytokines
Anti-Inflammatory Agents
inflammation
animal models
Cytokines
Inflammation
colon
Colon
Glucans
Interleukin-17
resistant starch
inflammatory bowel disease
Gastrointestinal Diseases
interleukin-1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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Intervention of isomaltodextrin mitigates intestinal inflammation in a dextran sodium sulfate-induced mouse model of colitis via inhibition of toll-like receptor-4. / Majumder, Kaustav; Fukuda, Toshihiko; Zhang, Hua; Sakurai, Takeo; Taniguchi, Yoshifumi; Watanabe, Hikaru; Mitsuzumi, Hitoshi; Matsui, Toshiro; Mine, Yoshinori.

In: Journal of Agricultural and Food Chemistry, Vol. 65, No. 4, 01.02.2017, p. 810-817.

Research output: Contribution to journalArticle

Majumder, Kaustav ; Fukuda, Toshihiko ; Zhang, Hua ; Sakurai, Takeo ; Taniguchi, Yoshifumi ; Watanabe, Hikaru ; Mitsuzumi, Hitoshi ; Matsui, Toshiro ; Mine, Yoshinori. / Intervention of isomaltodextrin mitigates intestinal inflammation in a dextran sodium sulfate-induced mouse model of colitis via inhibition of toll-like receptor-4. In: Journal of Agricultural and Food Chemistry. 2017 ; Vol. 65, No. 4. pp. 810-817.
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