Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity

Caspar Ohnmacht, Rute Marques, Laura Presley, Shinichiro Sawa, Matthias Lochner, Gérard Eberl

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The mammalian intestine provides a unique niche for a large community of bacterial symbionts that complements the host in digestive and anabolic pathways, as well as in protection from pathogens. Only a few bacterial phyla have adapted to this predominantly anaerobic environment, but hundreds of different species create an ecosystem that affects many facets of the host's physiology. Recent data show how particular symbionts are involved in the maturation of the immune system, in the intestine and beyond, and how dysbiosis, or alteration of that community, can deregulate immunity and lead to immunopathology. The extensive and dynamic interactions between the symbionts and the immune system are key to homeostasis and health, and require all the blends of so-called regulatory and pro-inflammatory immune reactions. Unfortunately, pro-inflammatory immunity leading to the generation of Th17 cells has been mainly associated with its role in immunopathology. Here we discuss the view that the immune system in general, and type 17 immunity in particular, develop to maintain the equilibrium of the host with its symbionts.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalCellular Microbiology
Volume13
Issue number5
DOIs
Publication statusPublished - May 1 2011
Externally publishedYes

Fingerprint

Immune System
Immunity
Intestines
Dysbiosis
Th17 Cells
Ecosystem
Homeostasis
Health
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity. / Ohnmacht, Caspar; Marques, Rute; Presley, Laura; Sawa, Shinichiro; Lochner, Matthias; Eberl, Gérard.

In: Cellular Microbiology, Vol. 13, No. 5, 01.05.2011, p. 653-659.

Research output: Contribution to journalReview article

Ohnmacht, Caspar ; Marques, Rute ; Presley, Laura ; Sawa, Shinichiro ; Lochner, Matthias ; Eberl, Gérard. / Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity. In: Cellular Microbiology. 2011 ; Vol. 13, No. 5. pp. 653-659.
@article{7cd5c7557a12414c97bbac9ffa6a4657,
title = "Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity",
abstract = "The mammalian intestine provides a unique niche for a large community of bacterial symbionts that complements the host in digestive and anabolic pathways, as well as in protection from pathogens. Only a few bacterial phyla have adapted to this predominantly anaerobic environment, but hundreds of different species create an ecosystem that affects many facets of the host's physiology. Recent data show how particular symbionts are involved in the maturation of the immune system, in the intestine and beyond, and how dysbiosis, or alteration of that community, can deregulate immunity and lead to immunopathology. The extensive and dynamic interactions between the symbionts and the immune system are key to homeostasis and health, and require all the blends of so-called regulatory and pro-inflammatory immune reactions. Unfortunately, pro-inflammatory immunity leading to the generation of Th17 cells has been mainly associated with its role in immunopathology. Here we discuss the view that the immune system in general, and type 17 immunity in particular, develop to maintain the equilibrium of the host with its symbionts.",
author = "Caspar Ohnmacht and Rute Marques and Laura Presley and Shinichiro Sawa and Matthias Lochner and G{\'e}rard Eberl",
year = "2011",
month = "5",
day = "1",
doi = "10.1111/j.1462-5822.2011.01577.x",
language = "English",
volume = "13",
pages = "653--659",
journal = "Cellular Microbiology",
issn = "1462-5814",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity

AU - Ohnmacht, Caspar

AU - Marques, Rute

AU - Presley, Laura

AU - Sawa, Shinichiro

AU - Lochner, Matthias

AU - Eberl, Gérard

PY - 2011/5/1

Y1 - 2011/5/1

N2 - The mammalian intestine provides a unique niche for a large community of bacterial symbionts that complements the host in digestive and anabolic pathways, as well as in protection from pathogens. Only a few bacterial phyla have adapted to this predominantly anaerobic environment, but hundreds of different species create an ecosystem that affects many facets of the host's physiology. Recent data show how particular symbionts are involved in the maturation of the immune system, in the intestine and beyond, and how dysbiosis, or alteration of that community, can deregulate immunity and lead to immunopathology. The extensive and dynamic interactions between the symbionts and the immune system are key to homeostasis and health, and require all the blends of so-called regulatory and pro-inflammatory immune reactions. Unfortunately, pro-inflammatory immunity leading to the generation of Th17 cells has been mainly associated with its role in immunopathology. Here we discuss the view that the immune system in general, and type 17 immunity in particular, develop to maintain the equilibrium of the host with its symbionts.

AB - The mammalian intestine provides a unique niche for a large community of bacterial symbionts that complements the host in digestive and anabolic pathways, as well as in protection from pathogens. Only a few bacterial phyla have adapted to this predominantly anaerobic environment, but hundreds of different species create an ecosystem that affects many facets of the host's physiology. Recent data show how particular symbionts are involved in the maturation of the immune system, in the intestine and beyond, and how dysbiosis, or alteration of that community, can deregulate immunity and lead to immunopathology. The extensive and dynamic interactions between the symbionts and the immune system are key to homeostasis and health, and require all the blends of so-called regulatory and pro-inflammatory immune reactions. Unfortunately, pro-inflammatory immunity leading to the generation of Th17 cells has been mainly associated with its role in immunopathology. Here we discuss the view that the immune system in general, and type 17 immunity in particular, develop to maintain the equilibrium of the host with its symbionts.

UR - http://www.scopus.com/inward/record.url?scp=79954667332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954667332&partnerID=8YFLogxK

U2 - 10.1111/j.1462-5822.2011.01577.x

DO - 10.1111/j.1462-5822.2011.01577.x

M3 - Review article

VL - 13

SP - 653

EP - 659

JO - Cellular Microbiology

JF - Cellular Microbiology

SN - 1462-5814

IS - 5

ER -