Intimal response of saphenous vein to intraluminal trauma by simulated angioscopic insertion

Makoto Hashizume, Yeng Yang, Spencer Galt, S. N.S. Murthy, Teruo Matsumoto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Endothelial damage after simulated angioscopic insertion was evaluated in 22 dogs by radioimmunoassay of endogenous 6-keto-prostaglandin F (stable product of prostacyclin produced by the endothelium) by means of a closed perfusion system and scanning electron microscopy. In 20 dogs, a 1.7 mm diameter polyethylene tube similar in size and physical characteristics to a commercially available angioscope was passed once into the distal venotomy site and out of the proximal venotomy site for a total distance of 15 cm in the left saphenous vein (group A) and 10 times in both directions in the right saphenous vein, destroying all valves (group B). The vein segments were examined immediately after simulated angioscopic insertion and at intervals of 2, 3, and 4 weeks. The remaining two dogs were used as control animals to establish baseline prostacyclin production. All veins were patent when harvested. Scanning electron microscopy revealed globular and contracted endothelial cells in some areas of group A veins, whereas partial longitudinal absence of endothelial cells was noted in group B veins. Intimal coverage was complete by 2 weeks in group A veins and between 3 and 4 weeks in group B veins. Prostacyclin synthesis of group B veins was significantly less than that of group A at day 1 and at 2 weeks after operation (p < 0.05), reaching that of control vein synthesis by 4 weeks. This study suggests that simulated angioscopic trauma of the luminal surface of the canine saphenous vein had no negative effect on early patency.

Original languageEnglish
Pages (from-to)862-868
Number of pages7
JournalJournal of Vascular Surgery
Volume5
Issue number6
DOIs
Publication statusPublished - Jan 1 1987

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Tunica Intima
Saphenous Vein
Veins
Wounds and Injuries
Epoprostenol
Dogs
Electron Scanning Microscopy
Angioscopes
Endothelial Cells
Polyethylene
Endothelium
Radioimmunoassay
Canidae
Perfusion

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Intimal response of saphenous vein to intraluminal trauma by simulated angioscopic insertion. / Hashizume, Makoto; Yang, Yeng; Galt, Spencer; Murthy, S. N.S.; Matsumoto, Teruo.

In: Journal of Vascular Surgery, Vol. 5, No. 6, 01.01.1987, p. 862-868.

Research output: Contribution to journalArticle

Hashizume, Makoto ; Yang, Yeng ; Galt, Spencer ; Murthy, S. N.S. ; Matsumoto, Teruo. / Intimal response of saphenous vein to intraluminal trauma by simulated angioscopic insertion. In: Journal of Vascular Surgery. 1987 ; Vol. 5, No. 6. pp. 862-868.
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