Intra-arterial combination chemotherapy using both regimen selected by chemosensitivity test and caffeine to increase effect for osteosarcoma in extremity

S. Yoh, T. Isayama, K. Yoshitake, A. Fujihara, T. Kanamiya, K. Ogata, K. Inoue, Y. Maehara, H. Baba

Research output: Contribution to journalArticlepeer-review

Abstract

We treated three patients with osteosarcoma in extremity with intra-arterial combination chemotherapy using a regimen selected by succinate dehydrogenase inhibition chemosensitivity test, and used caffeine to enhance its effect. In two patients with osteosarcoma in distal diametaphysis of the radius and extraskeletal osteosarcoma in sole of the foot, the effect of intra-arterial combination chemotherapy was increased and followed by the functional limb salvage procedure. But in one patient with osteosarcoma in the proximal tibia, the effect of pre-operative intraarterial combination chemotherapy could not be increased, so amputation was required. He was changed to a post-operative intra-venous combination chemotherapy regimen selected by chemosensitivity test of the surgical material. All patients have been continuously disease-free at five to twelve months after surgery.

Original languageEnglish
Pages (from-to)2315-2319
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume21
Issue number13
Publication statusPublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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