Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: Preliminary report of two cases

S. Suzuki; O. Ito; T. Sayama; S. Yamaguchi; K. Goto; T. Sasaki

doi:10.1007/s00234-005-0014-7

Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: Preliminary report of two cases

S. Suzuki, O. Ito, T. Sayama, S. Yamaguchi, K. Goto, T. Sasaki

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.

Original language	English
Pages (from-to)	50-53
Number of pages	4
Journal	Neuroradiology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1007/s00234-005-0014-7
Publication status	Published - Jan 2006

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

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abstract = "We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.",

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AU - Sayama, T.

AU - Yamaguchi, S.

AU - Goto, K.

AU - Sasaki, T.

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AB - We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.

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