Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

Md Monsur Ali, Motoi Oishi, Fumi Nagatsugi, Kenya Mori, Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

(Chemical Equation Presented) One mismatch is discriminated in a target mRNA sequence by an inducible alkylation system based on sulfide precursors to the nucleoside 2-amino-6-vinylpurine (see scheme). The reactive oligonucleotides were delivered into the cell as poly(ethylene glycol) (PEG) conjugates in polyion-complex (PIC) micelles and showed antisense activity of high selectivity and greater potency than that of the natural antisense oligonucleotide.

Original languageEnglish
Pages (from-to)3136-3140
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number19
DOIs
Publication statusPublished - May 5 2006

Fingerprint

Oligonucleotides
Alkylation
Polyethylene glycols
Antisense Oligonucleotides
Micelles
Sulfides
Nucleosides
Messenger RNA
2-amino-6-vinylpurine

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide. / Ali, Md Monsur; Oishi, Motoi; Nagatsugi, Fumi; Mori, Kenya; Nagasaki, Yukio; Kataoka, Kazunori; Sasaki, Shigeki.

In: Angewandte Chemie - International Edition, Vol. 45, No. 19, 05.05.2006, p. 3136-3140.

Research output: Contribution to journalArticle

Ali, Md Monsur ; Oishi, Motoi ; Nagatsugi, Fumi ; Mori, Kenya ; Nagasaki, Yukio ; Kataoka, Kazunori ; Sasaki, Shigeki. / Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide. In: Angewandte Chemie - International Edition. 2006 ; Vol. 45, No. 19. pp. 3136-3140.
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