Intracellular logistics of BST-2/Tetherin

Hideaki Fujita, Keiko Fujimoto, Kenzo Tokunaga, Yoshitaka Tanaka

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Bone marrow stromal antigen 2 (BST-2) is a type II membrane protein with two targeting signals, one of which is located in the cytoplasmic domain and contains a non-canonical dual tyrosine-based motif responsible for its endocytosis from the plasma membrane, and the other is a C-terminal glycosylphosphatidylinositol anchor that facilitates its association with detergent-resistant membranes/lipid rafts and targeting to the apical domain in polarized epithelial cells. Due to its unusual topology at the membrane, BST-2 takes unique and complicated trafficking routes in cells. Recently, a physiological role for BST-2 as the "tetherin" molecule for viruses, especially for HIV-1, has been extensively examined. These studies have shown that the biosynthesis, intracellular trafficking, localization, and structure of human BST-2 are closely related to its antiviral activity. This review provides an overview of the intracellular logistics of human BST-2.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalCurrent HIV Research
Volume10
Issue number4
DOIs
Publication statusPublished - Jun 2012

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology

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