Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks

T. Takagi, T. Bungo, T. Tachibana, E. S. Saito, S. Saito, I. Yamasaki, S. Tomonaga, D. M. Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

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Abstract

It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the mammalian and chicken brain, is involved in the functioning of the GABAergic system. A previous study has shown that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks; however, the precise relationship between the GABAergic system and L-PA has not been clarified. In the present study, the role of the GABA-A or GABA-B receptors in the suppression of food intake and induction of sleeping-like behavior by L-PA was investigated. Chicks were injected i.c.v. with the GABA-A antagonist picrotoxin or GABA-B antagonist CGP54626 along with L-PA. Although suppression of food intake by L-PA was restored partially by co-injection with CGP54626, but not picrotoxin, sleep-like behavior induced by L-PA was suppressed significantly by both antagonists. These results suggested that L-PA activated both GABA-A and GABA-B receptors, and GABA-B receptors alone contributed to food intake whereas both receptors contributed to sleep-like behavior.

Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalJournal of Neuroscience Research
Volume73
Issue number2
DOIs
Publication statusPublished - Jul 15 2003

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GABA-B Receptor Antagonists
gamma-Aminobutyric Acid
GABA-B Receptors
Picrotoxin
Sleep
Eating
GABA-A Receptor Antagonists
Injections
pipecolic acid
Lysine
Chickens

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks. / Takagi, T.; Bungo, T.; Tachibana, T.; Saito, E. S.; Saito, S.; Yamasaki, I.; Tomonaga, S.; Denbow, D. M.; Furuse, Mitsuhiro.

In: Journal of Neuroscience Research, Vol. 73, No. 2, 15.07.2003, p. 270-275.

Research output: Contribution to journalArticle

Takagi, T. ; Bungo, T. ; Tachibana, T. ; Saito, E. S. ; Saito, S. ; Yamasaki, I. ; Tomonaga, S. ; Denbow, D. M. ; Furuse, Mitsuhiro. / Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks. In: Journal of Neuroscience Research. 2003 ; Vol. 73, No. 2. pp. 270-275.
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