Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken

Takashi Bungo, Masataka Shimojo, Yasuhisa Masuda, Tetsuya Tachibanab, Shin Ji Tanaka, Kunio Sugahara, Mitsuhiro Furuse

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Recently, it has been suggested that leptin plays an important role in regulation of food intake and metabolism in rats and mice, however, the effect of central administration of leptin on food intake in chicks has not been reported. We have investigated the anorexigenic effect of leptin administered by intracerebroventricular (i.c.v.) injection in chicks using mouse leptin, which shows 97% homology to chicken leptin. Three experiments were conducted. After being deprived of food for 3 h, male broiler chicks were administered leptin by i.c.v, injection at dose levels of 0, 0.2, 1.0 and 5.0 p.g (Experiment 1) or 0, 2.5 and 5.0 μg (Experiment 2). The birds were allowed free access to the diet for 2 h (Experiment 1) and 24 h (Experiment 2) after treatment. Male Single Comb White Leghorn chicks were used in Experiment 3 and were treated in the same manner as in Experiment 1. In all experiments, central administration of mouse leptin did not influence food intake in the time periods examined. It appears that either mouse leptin does not bind to the chicken leptin receptor or in the chicken brain the leptin receptor may be absent.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalBrain Research
Volume817
Issue number1-2
DOIs
Publication statusPublished - Jan 30 1999

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Leptin
Chickens
Eating
Leptin Receptors
Appetite Regulation
Comb and Wattles
Injections
Birds
Diet
Food
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken. / Bungo, Takashi; Shimojo, Masataka; Masuda, Yasuhisa; Tachibanab, Tetsuya; Tanaka, Shin Ji; Sugahara, Kunio; Furuse, Mitsuhiro.

In: Brain Research, Vol. 817, No. 1-2, 30.01.1999, p. 196-198.

Research output: Contribution to journalArticle

Bungo, T, Shimojo, M, Masuda, Y, Tachibanab, T, Tanaka, SJ, Sugahara, K & Furuse, M 1999, 'Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken', Brain Research, vol. 817, no. 1-2, pp. 196-198. https://doi.org/10.1016/S0006-8993(98)01223-2
Bungo T, Shimojo M, Masuda Y, Tachibanab T, Tanaka SJ, Sugahara K et al. Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken. Brain Research. 1999 Jan 30;817(1-2):196-198. https://doi.org/10.1016/S0006-8993(98)01223-2
Bungo, Takashi ; Shimojo, Masataka ; Masuda, Yasuhisa ; Tachibanab, Tetsuya ; Tanaka, Shin Ji ; Sugahara, Kunio ; Furuse, Mitsuhiro. / Intracerebroventricular administration of mouse leptin does not reduce food intake in the chicken. In: Brain Research. 1999 ; Vol. 817, No. 1-2. pp. 196-198.
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