TY - JOUR
T1 - Intracerebroventricular injection of agouti-related protein attenuates the anorexigenic effect of alpha-melanocyte stimulating hormone in neonatal chicks
AU - Tachibana, Tetsuya
AU - Sugahara, Kunio
AU - Ohgushi, Atsushi
AU - Ando, Ryuichi
AU - Kawakami, Shin Ichi
AU - Yoshimatsu, Takao
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and Uehara Memorial Foundation for MF.
PY - 2001/6/8
Y1 - 2001/6/8
N2 - It is well known that α-melanocyte stimulating hormone (α-MSH) inhibits feeding via melanocortin receptor-4 (MC4R) in the mammalian brain. The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether human AGRP (86-132) antagonizes the anorexigenic effect of α-MSH in broiler chicks. Intracerebroventricular injection of AGRP attenuated the anorexigenic effect of α-MSH. Furthermore, AGRP stimulated food intake of layer-type chicks under an ad libitum feeding condition but not broiler chicks, suggesting that the orexigenic effect of AGRP is different between two breeds. These also imply that the extent of the anorexigenic effect of endogenous α-MSH is different among two breeds. This may be a part of the difference in food intake between two breeds.
AB - It is well known that α-melanocyte stimulating hormone (α-MSH) inhibits feeding via melanocortin receptor-4 (MC4R) in the mammalian brain. The anorexigenic effect of α-MSH is attenuated by agouti-related protein (AGRP), an antagonist for MC4R. Present studies were carried out to clarify whether human AGRP (86-132) antagonizes the anorexigenic effect of α-MSH in broiler chicks. Intracerebroventricular injection of AGRP attenuated the anorexigenic effect of α-MSH. Furthermore, AGRP stimulated food intake of layer-type chicks under an ad libitum feeding condition but not broiler chicks, suggesting that the orexigenic effect of AGRP is different between two breeds. These also imply that the extent of the anorexigenic effect of endogenous α-MSH is different among two breeds. This may be a part of the difference in food intake between two breeds.
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U2 - 10.1016/S0304-3940(01)01827-4
DO - 10.1016/S0304-3940(01)01827-4
M3 - Article
C2 - 11376901
AN - SCOPUS:0035827590
SN - 0304-3940
VL - 305
SP - 131
EP - 134
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -