Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks

Tetsuya Tachibana, Kunio Sugahara, Atsushi Ohgushi, Ryuichi Ando, Kouichi Sashihara, Takao Yoshimatsu, Mitsuhiro Furuse

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To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5-39) on food intake. Intracerebroventricular co-injection of exendin (5-39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5-39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalBrain Research
Issue number2
Publication statusPublished - Oct 12 2001


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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