Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks

Tetsuya Tachibana; Kunio Sugahara; Atsushi Ohgushi; Ryuichi Ando; Kouichi Sashihara; Takao Yoshimatsu; Mitsuhiro Furuse

doi:10.1016/S0006-8993(01)02943-2

Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks

Tetsuya Tachibana, Kunio Sugahara, Atsushi Ohgushi, Ryuichi Ando, Kouichi Sashihara, Takao Yoshimatsu, Mitsuhiro Furuse

Animal and Marine Bioresource Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5-39) on food intake. Intracerebroventricular co-injection of exendin (5-39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5-39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.

Original language	English
Pages (from-to)	234-237
Number of pages	4
Journal	Brain Research
Volume	915
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02943-2
Publication status	Published - Oct 12 2001

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(01)02943-2

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@article{78ca2173879945bca9b1ac3fcbb17263,

title = "Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks",

abstract = "To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5-39) on food intake. Intracerebroventricular co-injection of exendin (5-39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5-39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.",

author = "Tetsuya Tachibana and Kunio Sugahara and Atsushi Ohgushi and Ryuichi Ando and Kouichi Sashihara and Takao Yoshimatsu and Mitsuhiro Furuse",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and Uehara Memorial Foundation.",

year = "2001",

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doi = "10.1016/S0006-8993(01)02943-2",

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T1 - Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks

AU - Tachibana, Tetsuya

AU - Sugahara, Kunio

AU - Ohgushi, Atsushi

AU - Ando, Ryuichi

AU - Sashihara, Kouichi

AU - Yoshimatsu, Takao

AU - Furuse, Mitsuhiro

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and Uehara Memorial Foundation.

PY - 2001/10/12

Y1 - 2001/10/12

N2 - To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5-39) on food intake. Intracerebroventricular co-injection of exendin (5-39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5-39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.

AB - To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5-39) on food intake. Intracerebroventricular co-injection of exendin (5-39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5-39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.

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JF - Molecular Brain Research

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ER -

Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks

Abstract

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