Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick

T. Bungo, S. I. Kawakami, A. Ohgushi, K. Sashihara, N. Saito, K. Sugahara, S. Hasegawa, D. M. Denbow, M. Furuse

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23 Citations (Scopus)

Abstract

It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-β-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume70
Issue number2-3
DOIs
Publication statusPublished - Nov 21 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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