Intracerebroventricular injection of ghrelin and growth hormone releasing factor inhibits food intake in neonatal chicks

Mitsuhiro Furuse, Tetsuya Tachibana, Atsushi Ohgushi, Ryuichi Ando, Takao Yoshimatsu, D. Michael Denbow

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)

Abstract

Growth hormone releasing factor (GRF) is known to stimulate feeding of rats. Ghrelin, a novel growth hormone (GH)-releasing acylated peptide, was recently isolated from rat stomach. It also stimulates the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R) and feeding in the rat. We have investigated the effects of ghrelin and GRF on food intake of the neonatal chick. In Experiment 1, 0, 1.25, 2.5 and 5 μg of ghrelin were administered intracerebroventricularly (i.c.v.) to ad libitum fed birds. In Experiment 2, the effect of (i.c.v.) injection of 0, 1.25, 2.5 and 5 μg of GRF was investigated. Both peptides strongly inhibited food intake of the chick during the 2-h post-injection period. In the third experiment, 0, 0.5, 1 and 2 μg of ghrelin was injected i.c.v. in chicks previously deprived of food for 3 h. Food intake was again inhibited by ghrelin in a dose-dependent manner. These results suggest that the mechanisms for feeding of the neonatal chick through GH release are different from mammals.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalNeuroscience Letters
Volume301
Issue number2
DOIs
Publication statusPublished - Mar 30 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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