Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks

Tetsuya Tachibana, Daichi Oikawa, Nami Adachi, Tim Boswell, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Glucagon-like peptide-1 (GLP-1), derived from proglucagon, is thought to act as a negative regulator of energy homeostasis in mammals, since intracerebroventricular (ICV) injection of GLP-1 inhibits feeding behavior and enhances energy expenditure. The anorexigenic effect of GLP-1 is also observed in chicks, but whether brain GLP-1 enhances energy expenditure has not been investigated. The aim of the present study was to clarify the effect of ICV injection of GLP-1 on energy expenditure as well as metabolic changes in chicks. The injection of GLP-1 did not affect energy expenditure calculated from oxygen consumption and carbon dioxide production. On the other hand, the injection of GLP-1 significantly decreased respiratory quotient, suggesting that brain GLP-1 shifted the use of energy sources from carbohydrates to lipids. In support of this, ICV injection of GLP-1 increased plasma non-esterified fatty acid concentration while plasma glucose concentration was decreased. In conclusion, GLP-1 appears to act in the brain as a metabolic modulator rather than as a regulator of total energy expenditure in chicks.

Original languageEnglish
Pages (from-to)1104-1108
Number of pages5
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Issue number4
Publication statusPublished - Aug 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology


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