Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks

Tetsuya Tachibana, Daichi Oikawa, Nami Adachi, Tim Boswell, Mitsuhiro Furuse

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1), derived from proglucagon, is thought to act as a negative regulator of energy homeostasis in mammals, since intracerebroventricular (ICV) injection of GLP-1 inhibits feeding behavior and enhances energy expenditure. The anorexigenic effect of GLP-1 is also observed in chicks, but whether brain GLP-1 enhances energy expenditure has not been investigated. The aim of the present study was to clarify the effect of ICV injection of GLP-1 on energy expenditure as well as metabolic changes in chicks. The injection of GLP-1 did not affect energy expenditure calculated from oxygen consumption and carbon dioxide production. On the other hand, the injection of GLP-1 significantly decreased respiratory quotient, suggesting that brain GLP-1 shifted the use of energy sources from carbohydrates to lipids. In support of this, ICV injection of GLP-1 increased plasma non-esterified fatty acid concentration while plasma glucose concentration was decreased. In conclusion, GLP-1 appears to act in the brain as a metabolic modulator rather than as a regulator of total energy expenditure in chicks.

Original languageEnglish
Pages (from-to)1104-1108
Number of pages5
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume147
Issue number4
DOIs
Publication statusPublished - Aug 1 2007

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Glucagon-Like Peptide 1
Lipid Metabolism
Injections
Energy Metabolism
Brain
Proglucagon
Plasmas
Mammals
Feeding Behavior
Carbon Dioxide
Oxygen Consumption
Modulators
Homeostasis
Fatty Acids
Carbohydrates
Oxygen
Lipids
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

Cite this

Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks. / Tachibana, Tetsuya; Oikawa, Daichi; Adachi, Nami; Boswell, Tim; Furuse, Mitsuhiro.

In: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Vol. 147, No. 4, 01.08.2007, p. 1104-1108.

Research output: Contribution to journalArticle

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