Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks

T. Tachibana, S. Tanaka, M. Furuse, S. Hasegawa, H. Kato, K. Sugahara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. We measured the concentrations of dopamine (DA), norepinephrine (NE), epinephrine (E) and 5-hydroxytryptamine (5-HT) in the hypothalamus of 21-d-old male brown-egg layer-type chicks after intracerebroventricular injection of glucagon-like peptide-1 (GLP-1). 2. The monoamine concentrations of the whole hypothalamus, paraventricular nucleus and lateral hypothalamic area were not significantly affected by GLP-1. 3. However, concentrations of DA, NE and E, but not 5-HT, in the ventromedial hypothalamic nucleus (VMH) were significantly decreased by GLP-1. 4. These observations suggest that the anorexigenic effect of GLP-I involves catecholaminergic systems in the VMH in the chick.

Original languageEnglish
Pages (from-to)122-126
Number of pages5
JournalBritish Poultry Science
Volume43
Issue number1
DOIs
Publication statusPublished - Mar 1 2002

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology

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