Intracerebroventricular injection of L-aspartic acid and L-asparagine induces sedative effects under an acute stressful condition in neonatal chicks

Haruka Yamane, Mari Asechi, Yousuke Tsuneyoshi, Isao Kurauchi, D. Michael Denbow, Mitsuhiro Furuse

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20 Citations (Scopus)

Abstract

The present study was conducted to clarify the central functions of L-aspartic acid (Asp) and L-asparagine (Asn) during an acute stressful condition in chicks. Intracerebroventricular (i.c.v.) injection of Asp and Asn (0.84 mol) attenuated the vocalization that normally occurs during social separation stress. Asp decreased the time spent in active wakefulness and induced sedation. Asn had a similar effect to Asp, although somewhat weaker. However, i.c.v. injection of Asp and Asn further enhanced plasma corticosterone release under social separation stress. Taken together, the i.c.v. injection of Asp and Asn has sedative effects under an acute stressful condition, which does not involve the hypothalamic-pituitary-adrenal axis.The Authors. Journal compilation.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalAnimal Science Journal
Volume80
Issue number3
DOIs
Publication statusPublished - Jun 1 2009

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

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