Abstract
Four experiments were conducted to clarify the central functions of l-serine and its analogs on an acute stressful condition. Intracerebroventricular (i.c.v.) injection of l-serine (0.21, 0.42 and 0.84 μmol) attenuated stress responses in a dose-dependent fashion, as well as induced sleep, in Experiment 1. The effects of l- and d-serine in Experiment 2, those of l-serine, phosphoserine, acetylserine and l-cysteine in Experiment 3 and those of l-serine, glycine and lysophosphatidylserine in Experiment 4 were compared at an equimolar basis (0.84 μmol). d-Serine, proposed as an endogenous agonist of N-methyl-d-aspatate (NMDA) receptor, did not have sedative and hypnotic effects as observed with l-serine. In contrast, all the analogs and derivatives of l-serine had a sedative effect, although with a different manner in several behavioral markers of stress such as spontaneous activity and distress vocalizations. No significant changes in plasma corticosterone concentration were observed in any experiment. Taken together, the i.c.v. injection of l-serine analogs and its derivatives have sedative and hypnotic effects under an acute stressful condition, which does not involve the hypothalamic-pituitary-adrenal axis. In conclusion, l-serine may be effective in improving anxiety or sleep disorders induced by psychological stressor.
| Original language | English |
|---|---|
| Pages (from-to) | 71-77 |
| Number of pages | 7 |
| Journal | Behavioural Brain Research |
| Volume | 170 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jun 3 2006 |
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All Science Journal Classification (ASJC) codes
- Behavioral Neuroscience
Cite this
Intracerebroventricular injection of l-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks. / Asechi, Mari; Tomonaga, Shozo; Tachibana, Tetsuya; Han, Li; Hayamizu, Kohsuke; Denbow, D. Michael; Furuse, Mitsuhiro.
In: Behavioural Brain Research, Vol. 170, No. 1, 03.06.2006, p. 71-77.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Intracerebroventricular injection of l-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks
AU - Asechi, Mari
AU - Tomonaga, Shozo
AU - Tachibana, Tetsuya
AU - Han, Li
AU - Hayamizu, Kohsuke
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
PY - 2006/6/3
Y1 - 2006/6/3
N2 - Four experiments were conducted to clarify the central functions of l-serine and its analogs on an acute stressful condition. Intracerebroventricular (i.c.v.) injection of l-serine (0.21, 0.42 and 0.84 μmol) attenuated stress responses in a dose-dependent fashion, as well as induced sleep, in Experiment 1. The effects of l- and d-serine in Experiment 2, those of l-serine, phosphoserine, acetylserine and l-cysteine in Experiment 3 and those of l-serine, glycine and lysophosphatidylserine in Experiment 4 were compared at an equimolar basis (0.84 μmol). d-Serine, proposed as an endogenous agonist of N-methyl-d-aspatate (NMDA) receptor, did not have sedative and hypnotic effects as observed with l-serine. In contrast, all the analogs and derivatives of l-serine had a sedative effect, although with a different manner in several behavioral markers of stress such as spontaneous activity and distress vocalizations. No significant changes in plasma corticosterone concentration were observed in any experiment. Taken together, the i.c.v. injection of l-serine analogs and its derivatives have sedative and hypnotic effects under an acute stressful condition, which does not involve the hypothalamic-pituitary-adrenal axis. In conclusion, l-serine may be effective in improving anxiety or sleep disorders induced by psychological stressor.
AB - Four experiments were conducted to clarify the central functions of l-serine and its analogs on an acute stressful condition. Intracerebroventricular (i.c.v.) injection of l-serine (0.21, 0.42 and 0.84 μmol) attenuated stress responses in a dose-dependent fashion, as well as induced sleep, in Experiment 1. The effects of l- and d-serine in Experiment 2, those of l-serine, phosphoserine, acetylserine and l-cysteine in Experiment 3 and those of l-serine, glycine and lysophosphatidylserine in Experiment 4 were compared at an equimolar basis (0.84 μmol). d-Serine, proposed as an endogenous agonist of N-methyl-d-aspatate (NMDA) receptor, did not have sedative and hypnotic effects as observed with l-serine. In contrast, all the analogs and derivatives of l-serine had a sedative effect, although with a different manner in several behavioral markers of stress such as spontaneous activity and distress vocalizations. No significant changes in plasma corticosterone concentration were observed in any experiment. Taken together, the i.c.v. injection of l-serine analogs and its derivatives have sedative and hypnotic effects under an acute stressful condition, which does not involve the hypothalamic-pituitary-adrenal axis. In conclusion, l-serine may be effective in improving anxiety or sleep disorders induced by psychological stressor.
UR - http://www.scopus.com/inward/record.url?scp=33748050146&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748050146&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2006.02.005
DO - 10.1016/j.bbr.2006.02.005
M3 - Article
C2 - 16574253
AN - SCOPUS:33748050146
VL - 170
SP - 71
EP - 77
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -