Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick

Mitsuhiro Furuse, Megumi Matsumoto, Jun Ichi Okumura, Kunio Sugahara, Shin Hasegawa

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1), structurally similar to glucagon, is synthesized from a larger precursor, preproglucagon, and has been postulated to be a novel incretin. Recently, it was reported that central administration of GLP-1 decreased food intake in rats. The amino acid sequences of GLP-1 are identical in all mammals, and chicken GLP-1 exhibits a high homology with mammalian GLP-1. The aim of this study was to elucidate whether central injection of mammalian or chicken GLP-1 inhibits food intake in the chick, and to compare their effects. Intracerebroventricular administration of mammalian and chicken GLP-1 strongly inhibited food intake of chicks. However, the suppressive effect of both GLP-1 on food intake was similar. These results show that GLP-1 with a variety of amino acid sequences may be the most potent inhibitor of food intake in the chicken.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalBrain Research
Volume755
Issue number1
DOIs
Publication statusPublished - Apr 25 1997
Externally publishedYes

Fingerprint

Glucagon-Like Peptide 1
Chickens
Eating
Injections
Amino Acid Sequence
Proglucagon
Incretins
Glucagon
Mammals

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick. / Furuse, Mitsuhiro; Matsumoto, Megumi; Okumura, Jun Ichi; Sugahara, Kunio; Hasegawa, Shin.

In: Brain Research, Vol. 755, No. 1, 25.04.1997, p. 167-169.

Research output: Contribution to journalArticle

Furuse, Mitsuhiro ; Matsumoto, Megumi ; Okumura, Jun Ichi ; Sugahara, Kunio ; Hasegawa, Shin. / Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick. In: Brain Research. 1997 ; Vol. 755, No. 1. pp. 167-169.
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