Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks

Takashi Bungo, Tomofumi Izumi, Kazuya Kawamura, Tomo Takagi, Hiroshi Ueda, Mitsuhiro Furuse

Research output: Contribution to journalArticle

23 Citations (Scopus)


This study was designed to compare the effects of muscimol (GABA A agonist), baclofen (GABAB agonist) and nipecotic acid (GABA uptake inhibitor) on food intake in two chicken strains (meat-type and layer-type chicks). The intracerebroventricular (ICV) injection of all GABA agents induced hyperphagia in layer-type chicks. However, in broiler chicks, there were similar tendencies with muscimol and nipecotic acid but not significantly different. Conversely, ICV injection of baclofen depressed feeding of broiler chicks. These results suggest that there are some differences in central GABAergic systems between these strains of chicks, but GABAergic systems have an important role in the regulation of food intake in neonatal chicks.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalBrain Research
Issue number1-2
Publication statusPublished - Dec 12 2003


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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