Intracerebroventricular injection of orexin-A stimulates monoamine metabolism but not HPA axis in neonatal chicks

Sachiko Katayama, Kazutaka Shigemi, Mark A. Cline, Mitsuhiro Furuse

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We investigated the effects of intracerebroventricular (ICV) injection of orexin-A on plasma corticosterone (CORT) concentration and brain monoamine metabolism to clarify the mechanism by which ICV orexin-A induced arousal in chicks. In Experiment 1, plasma CORT concentrations were measured as an indicator of hypothalamic-pituitary-adrenal (HPA) axis activity. There was no significant difference in CORT concentration between the control and orexin-A administered groups. In Experiment 2, the concentrations of monoamines (norepinephrine, dopamine and serotonin), their metabolites, and their metabolic turnover rates in the telencephalon, mesencephalon, and diencephalon were investigated. All metabolic turnover rates studied were increased at all brain sites after ICV orexin-A injection. In conclusion, the HPA axis does not appear to be involved in arousal-inducing mechanisms of orexin-A in neonatal chicks; however, several monoaminergic systems do.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalNeuroscience Letters
Volume484
Issue number2
DOIs
Publication statusPublished - Oct 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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