Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks

Mitsuhiro Furuse, R. Ando, T. Bungo, R. Ao, Masataka Shimojo, Y. Masuda

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

1. Recently, 2 novel neuropeptides were discovered, both derived from the same precursor by proteolytic processing, which bind and activate 2 closely related orphan G protein-coupled receptors, Named orexin-A and -B (Sakurai et al., 1998). Both stimulate food intake when administered centrally to rats. 2. Our aim was to elucidate whether central injection of mammalian orexin-A or -B stimulates food intake in the chick. 3. Under conditions of free access to food, orexin-A did not alter the food intake of chicks, but cumulative food intake was significantly suppressed by orexin-B. 4. The orexin-B was then administered to chicks deprived of food for 3 h to confirm its suppressive effect. No significant effect of orexin-B on food intake was detected. 5. Central injection of orexin-B did not modify food intake when appetite was stimulated by fasting. 6. Neither of these orexins appears to stimulate feeding in chicks.

Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalBritish Poultry Science
Volume40
Issue number5
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

food intake
Eating
chicks
injection
Injections
neuropeptides
appetite
fasting
Orexins
Food
Appetite
G-Protein-Coupled Receptors
Neuropeptides
Fasting
rats

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology

Cite this

Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. / Furuse, Mitsuhiro; Ando, R.; Bungo, T.; Ao, R.; Shimojo, Masataka; Masuda, Y.

In: British Poultry Science, Vol. 40, No. 5, 01.01.1999, p. 698-700.

Research output: Contribution to journalArticle

Furuse, Mitsuhiro ; Ando, R. ; Bungo, T. ; Ao, R. ; Shimojo, Masataka ; Masuda, Y. / Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. In: British Poultry Science. 1999 ; Vol. 40, No. 5. pp. 698-700.
@article{e3f7b3390ffc463f9c3dae9f301336fb,
title = "Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks",
abstract = "1. Recently, 2 novel neuropeptides were discovered, both derived from the same precursor by proteolytic processing, which bind and activate 2 closely related orphan G protein-coupled receptors, Named orexin-A and -B (Sakurai et al., 1998). Both stimulate food intake when administered centrally to rats. 2. Our aim was to elucidate whether central injection of mammalian orexin-A or -B stimulates food intake in the chick. 3. Under conditions of free access to food, orexin-A did not alter the food intake of chicks, but cumulative food intake was significantly suppressed by orexin-B. 4. The orexin-B was then administered to chicks deprived of food for 3 h to confirm its suppressive effect. No significant effect of orexin-B on food intake was detected. 5. Central injection of orexin-B did not modify food intake when appetite was stimulated by fasting. 6. Neither of these orexins appears to stimulate feeding in chicks.",
author = "Mitsuhiro Furuse and R. Ando and T. Bungo and R. Ao and Masataka Shimojo and Y. Masuda",
year = "1999",
month = "1",
day = "1",
doi = "10.1080/00071669987115",
language = "English",
volume = "40",
pages = "698--700",
journal = "British Poultry Science",
issn = "0007-1668",
publisher = "Taylor and Francis Ltd.",
number = "5",

}

TY - JOUR

T1 - Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks

AU - Furuse, Mitsuhiro

AU - Ando, R.

AU - Bungo, T.

AU - Ao, R.

AU - Shimojo, Masataka

AU - Masuda, Y.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - 1. Recently, 2 novel neuropeptides were discovered, both derived from the same precursor by proteolytic processing, which bind and activate 2 closely related orphan G protein-coupled receptors, Named orexin-A and -B (Sakurai et al., 1998). Both stimulate food intake when administered centrally to rats. 2. Our aim was to elucidate whether central injection of mammalian orexin-A or -B stimulates food intake in the chick. 3. Under conditions of free access to food, orexin-A did not alter the food intake of chicks, but cumulative food intake was significantly suppressed by orexin-B. 4. The orexin-B was then administered to chicks deprived of food for 3 h to confirm its suppressive effect. No significant effect of orexin-B on food intake was detected. 5. Central injection of orexin-B did not modify food intake when appetite was stimulated by fasting. 6. Neither of these orexins appears to stimulate feeding in chicks.

AB - 1. Recently, 2 novel neuropeptides were discovered, both derived from the same precursor by proteolytic processing, which bind and activate 2 closely related orphan G protein-coupled receptors, Named orexin-A and -B (Sakurai et al., 1998). Both stimulate food intake when administered centrally to rats. 2. Our aim was to elucidate whether central injection of mammalian orexin-A or -B stimulates food intake in the chick. 3. Under conditions of free access to food, orexin-A did not alter the food intake of chicks, but cumulative food intake was significantly suppressed by orexin-B. 4. The orexin-B was then administered to chicks deprived of food for 3 h to confirm its suppressive effect. No significant effect of orexin-B on food intake was detected. 5. Central injection of orexin-B did not modify food intake when appetite was stimulated by fasting. 6. Neither of these orexins appears to stimulate feeding in chicks.

UR - http://www.scopus.com/inward/record.url?scp=0033256048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033256048&partnerID=8YFLogxK

U2 - 10.1080/00071669987115

DO - 10.1080/00071669987115

M3 - Article

C2 - 10670685

AN - SCOPUS:0033256048

VL - 40

SP - 698

EP - 700

JO - British Poultry Science

JF - British Poultry Science

SN - 0007-1668

IS - 5

ER -