Intracerebroventricular injection of pipecolic acid inhibits food intake and induces sleeping-like behaviors in the neonatal chick

Tomo Takagi, Ryuichi Ando, Atsushi Ohgushi, Tomoe Yamashita, Eriko Dobashi, Hazizul Hussain-Yusuf, Ryoji Onodera, Takashi Bungo, Hiroyuki Sato, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-Lysine (L-Lys) in the brain, is involved in the functioning of Γ-aminobutyric acid. In the present work the effect of intracerebroventricular (i.c.v.) administration of L-PA, and its relatives, on food intake and behavior in neonatal chicks was investigated. The i.c.v. injection of 1 mg of L-PA and D-PA significantly inhibited food intake during the 2 h following injection, whereas greater than 2 mg of L-Lys was required to inhibit food intake. In behavioral tests, the i.c.v. injection of L-PA reduced active wakefulness and feeding behavior while inducing sleeping-like behavior in chicks. These results suggest that L-PA has an important role for the regulation of behaviors in the neonatal chick after conversion from L-Lys in the brain.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalNeuroscience Letters
Volume310
Issue number2-3
DOIs
Publication statusPublished - Sep 14 2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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