Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

Hitoshi Nishimura, Toshiki Yajima, Yoshiko Kagimoto, Mutsuhiro Ohata, Taketo Watase, Kenji Kishihara, Fumi Goshima, Yukihiro Nishiyama, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Mice depleted of γδ T cells by in vivo administration of anti-TCRγδ monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the γδ T-cell-depleted mice. Mice deficient in the Vδ1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial γδ T cells bearing Vδ1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.

    Original languageEnglish
    Pages (from-to)4927-4930
    Number of pages4
    JournalJournal of virology
    Volume78
    Issue number9
    DOIs
    Publication statusPublished - May 1 2004

    Fingerprint

    Human herpesvirus 2
    Human Herpesvirus 2
    Adaptive Immunity
    Innate Immunity
    T-lymphocytes
    T-Lymphocytes
    mice
    Infection
    infection
    monoclonal antibodies
    Monoclonal Antibodies
    innate immunity
    adaptive immunity

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

    Cite this

    Nishimura, H., Yajima, T., Kagimoto, Y., Ohata, M., Watase, T., Kishihara, K., ... Yoshikai, Y. (2004). Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2. Journal of virology, 78(9), 4927-4930. https://doi.org/10.1128/JVI.78.9.4927-4930.2004

    Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2. / Nishimura, Hitoshi; Yajima, Toshiki; Kagimoto, Yoshiko; Ohata, Mutsuhiro; Watase, Taketo; Kishihara, Kenji; Goshima, Fumi; Nishiyama, Yukihiro; Yoshikai, Yasunobu.

    In: Journal of virology, Vol. 78, No. 9, 01.05.2004, p. 4927-4930.

    Research output: Contribution to journalArticle

    Nishimura, H, Yajima, T, Kagimoto, Y, Ohata, M, Watase, T, Kishihara, K, Goshima, F, Nishiyama, Y & Yoshikai, Y 2004, 'Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2', Journal of virology, vol. 78, no. 9, pp. 4927-4930. https://doi.org/10.1128/JVI.78.9.4927-4930.2004
    Nishimura, Hitoshi ; Yajima, Toshiki ; Kagimoto, Yoshiko ; Ohata, Mutsuhiro ; Watase, Taketo ; Kishihara, Kenji ; Goshima, Fumi ; Nishiyama, Yukihiro ; Yoshikai, Yasunobu. / Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2. In: Journal of virology. 2004 ; Vol. 78, No. 9. pp. 4927-4930.
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