Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice

Yukiko Masamoto, Fuminori Kawabata, Tohru Fushiki

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The main aim of this study was to elucidate whether thermosensitive transient receptor potential channels (thermoTRPs) play a role in controlling autonomic thermoregulation. We investigated whether the activation of certain thermoTRPs, TRPV1, TRPV3, TRPM8, and TRPA1, would induce autonomic thermoregulation by administering chemical agonists derived from spices and aroma chemicals of these channels to anesthetized mice. We discovered the following: Capsaicin, a TRPV1 agonist, enhanced thermogenesis and heat diffusion; thymol and ethyl vanillin, TRPV3 agonists, did not have any effect on thermogenesis or heat diffusion; menthol and 1,8-cineole, TRPM8 agonists, enhanced thermogenesis; and allyl isothiocyanate and cinnamaldehyde, TRPA1 agonists, enhanced thermogenesis and inhibited heat diffusion. These results suggest that these thermoTRP agonists derived from spices and aroma chemicals modulate autonomic thermoregulation, except for TRPV3 agonists. Our findings suggest the possibility that each thermoTRP is a key sensor inducing reasonable autonomic thermoregulation according to its own activated temperature range.

Original languageEnglish
Pages (from-to)1021-1027
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number5
DOIs
Publication statusPublished - Jun 18 2009

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Thermogenesis
Body Temperature Regulation
Transient Receptor Potential Channels
Spices
Hot Temperature
Menthol
Thymol
Capsaicin
Chemical activation
Sensors
Temperature

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. / Masamoto, Yukiko; Kawabata, Fuminori; Fushiki, Tohru.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 5, 18.06.2009, p. 1021-1027.

Research output: Contribution to journalArticle

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