TY - JOUR
T1 - Intralesional fibrous septum in chordoma
T2 - A clinicopathologic and immunohistochemical study of 122 lesions
AU - Naka, Takahiko
AU - Boltze, Carsten
AU - Kuester, Doerthe
AU - Samii, Amir
AU - Herold, Christian
AU - Ostertag, Helmut
AU - Iwamoto, Yukihide
AU - Oda, Yoshinao
AU - Tsuneyoshi, Masazumi
AU - Roessner, Albert
PY - 2005/8
Y1 - 2005/8
N2 - Intralesional fibrous septum (IFS) generally is considered a reactive tissue in chordoma; however, little is known about its significance. We studied 122 chordomas for IFS using immunohistochemical techniques and compared IFS and lobular growth patterns (LGPs) formed by IFS with clinicopathologic parameters. Seventy-nine tumors (65%) revealed IFS. However, IFS frequently was infiltrated and interrupted by tumor cells with increased expression of proteases; only 33 (42%) of 79 tumors had LGP. In non-skull base chordomas, IFS and LGP were associated with nuclear pleomorphism, a previously described prognostic indicator, mitosis, and the MIB-1 labeling index, indicating a role of IFS and LGP in tumor growth or progression. Paradoxically, patients without LGP tended to have a worse prognosis than those with LGP. We believe that IFS exerts diverse influences on chordoma; however, invasion of IFS leading to loss of the LGP indicates advanced stages of tumor development, possibly predicting an unfavorable prognosis in chordoma.
AB - Intralesional fibrous septum (IFS) generally is considered a reactive tissue in chordoma; however, little is known about its significance. We studied 122 chordomas for IFS using immunohistochemical techniques and compared IFS and lobular growth patterns (LGPs) formed by IFS with clinicopathologic parameters. Seventy-nine tumors (65%) revealed IFS. However, IFS frequently was infiltrated and interrupted by tumor cells with increased expression of proteases; only 33 (42%) of 79 tumors had LGP. In non-skull base chordomas, IFS and LGP were associated with nuclear pleomorphism, a previously described prognostic indicator, mitosis, and the MIB-1 labeling index, indicating a role of IFS and LGP in tumor growth or progression. Paradoxically, patients without LGP tended to have a worse prognosis than those with LGP. We believe that IFS exerts diverse influences on chordoma; however, invasion of IFS leading to loss of the LGP indicates advanced stages of tumor development, possibly predicting an unfavorable prognosis in chordoma.
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U2 - 10.1309/5DLWL8EA7JUDWNVL
DO - 10.1309/5DLWL8EA7JUDWNVL
M3 - Article
C2 - 16040302
AN - SCOPUS:23044459881
SN - 0002-9173
VL - 124
SP - 288
EP - 294
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 2
ER -