Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

Minako Hirahashi, Takashi Yao, Takayuki Matsumoto, Ken Ichi Nishiyama, Masafumi Oya, Mitsuo Iida, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The aim of this investigation was to clarify the histological characteristics of gastric cancer in the young. Twenty-three surgically resected specimens of young patients (under 30 years of age; young group) with intramucosal cancer of poorly differentiated type and 42 surgically resected specimens of elderly patients (more than 40 years of age; elderly group) with tumors of the identical depth and histological type were examined. The degree of gastritis and Helicobacter pylori (H. pylori) infection was evaluated according to the updated Sydney system. The incidence of H. pylori infection was significantly higher in the young group than in the elderly group (96 vs 36%, P<0.05). Within the background mucosa, antral chronic inflammatory infiltrates with lymphoid-follicle hyperplasia were more severe, and intestinal metaplasia was less frequent in the young group than in the elderly group. Glandular atrophy was not different between the two groups. Intramucosal gastric adenocarcinomas of poorly differentiated type in the young may be associated with H. pylori infection with antral chronic inflammation with lymphoid-follicle hyperplasia, regardless of the existence of intestinal metaplasia within the background gastric mucosa.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalModern Pathology
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

Fingerprint

Helicobacter Infections
Helicobacter pylori
Hyperplasia
Stomach
Adenocarcinoma
Metaplasia
Gastritis
Gastric Mucosa
Stomach Neoplasms
Atrophy
Neoplasms
Mucous Membrane
Inflammation
Antral
Incidence

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia. / Hirahashi, Minako; Yao, Takashi; Matsumoto, Takayuki; Nishiyama, Ken Ichi; Oya, Masafumi; Iida, Mitsuo; Tsuneyoshi, Masazumi.

In: Modern Pathology, Vol. 20, No. 1, 01.01.2007, p. 29-34.

Research output: Contribution to journalArticle

Hirahashi, Minako ; Yao, Takashi ; Matsumoto, Takayuki ; Nishiyama, Ken Ichi ; Oya, Masafumi ; Iida, Mitsuo ; Tsuneyoshi, Masazumi. / Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia. In: Modern Pathology. 2007 ; Vol. 20, No. 1. pp. 29-34.
@article{1d5599df13da4ba4bca2b6eaca4b03c5,
title = "Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia",
abstract = "The aim of this investigation was to clarify the histological characteristics of gastric cancer in the young. Twenty-three surgically resected specimens of young patients (under 30 years of age; young group) with intramucosal cancer of poorly differentiated type and 42 surgically resected specimens of elderly patients (more than 40 years of age; elderly group) with tumors of the identical depth and histological type were examined. The degree of gastritis and Helicobacter pylori (H. pylori) infection was evaluated according to the updated Sydney system. The incidence of H. pylori infection was significantly higher in the young group than in the elderly group (96 vs 36{\%}, P<0.05). Within the background mucosa, antral chronic inflammatory infiltrates with lymphoid-follicle hyperplasia were more severe, and intestinal metaplasia was less frequent in the young group than in the elderly group. Glandular atrophy was not different between the two groups. Intramucosal gastric adenocarcinomas of poorly differentiated type in the young may be associated with H. pylori infection with antral chronic inflammation with lymphoid-follicle hyperplasia, regardless of the existence of intestinal metaplasia within the background gastric mucosa.",
author = "Minako Hirahashi and Takashi Yao and Takayuki Matsumoto and Nishiyama, {Ken Ichi} and Masafumi Oya and Mitsuo Iida and Masazumi Tsuneyoshi",
year = "2007",
month = "1",
day = "1",
doi = "10.1038/modpathol.3800714",
language = "English",
volume = "20",
pages = "29--34",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

AU - Hirahashi, Minako

AU - Yao, Takashi

AU - Matsumoto, Takayuki

AU - Nishiyama, Ken Ichi

AU - Oya, Masafumi

AU - Iida, Mitsuo

AU - Tsuneyoshi, Masazumi

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The aim of this investigation was to clarify the histological characteristics of gastric cancer in the young. Twenty-three surgically resected specimens of young patients (under 30 years of age; young group) with intramucosal cancer of poorly differentiated type and 42 surgically resected specimens of elderly patients (more than 40 years of age; elderly group) with tumors of the identical depth and histological type were examined. The degree of gastritis and Helicobacter pylori (H. pylori) infection was evaluated according to the updated Sydney system. The incidence of H. pylori infection was significantly higher in the young group than in the elderly group (96 vs 36%, P<0.05). Within the background mucosa, antral chronic inflammatory infiltrates with lymphoid-follicle hyperplasia were more severe, and intestinal metaplasia was less frequent in the young group than in the elderly group. Glandular atrophy was not different between the two groups. Intramucosal gastric adenocarcinomas of poorly differentiated type in the young may be associated with H. pylori infection with antral chronic inflammation with lymphoid-follicle hyperplasia, regardless of the existence of intestinal metaplasia within the background gastric mucosa.

AB - The aim of this investigation was to clarify the histological characteristics of gastric cancer in the young. Twenty-three surgically resected specimens of young patients (under 30 years of age; young group) with intramucosal cancer of poorly differentiated type and 42 surgically resected specimens of elderly patients (more than 40 years of age; elderly group) with tumors of the identical depth and histological type were examined. The degree of gastritis and Helicobacter pylori (H. pylori) infection was evaluated according to the updated Sydney system. The incidence of H. pylori infection was significantly higher in the young group than in the elderly group (96 vs 36%, P<0.05). Within the background mucosa, antral chronic inflammatory infiltrates with lymphoid-follicle hyperplasia were more severe, and intestinal metaplasia was less frequent in the young group than in the elderly group. Glandular atrophy was not different between the two groups. Intramucosal gastric adenocarcinomas of poorly differentiated type in the young may be associated with H. pylori infection with antral chronic inflammation with lymphoid-follicle hyperplasia, regardless of the existence of intestinal metaplasia within the background gastric mucosa.

UR - http://www.scopus.com/inward/record.url?scp=33845717942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845717942&partnerID=8YFLogxK

U2 - 10.1038/modpathol.3800714

DO - 10.1038/modpathol.3800714

M3 - Article

C2 - 17041565

AN - SCOPUS:33845717942

VL - 20

SP - 29

EP - 34

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 1

ER -