Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction

Tadashi Suga, Koichi Okita, Noriteru Morita, Takashi Yokota, Kagami Hirabayashi, Masahiro Horiuchi, Shingo Takada, Tomohiro Takahashi, Masashi Omokawa, Shintaro Kinugawa, Hiroyuki Tsutsui

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Abstract

Although recent studies have reported that low-intensity resistance training with blood flow restriction could stress the muscle effectively and provide rapid muscle hypertrophy and strength gain equivalent to those of high-intensity resistance training, the exact mechanism and its generality have not yet been clarified. We investigated the intramuscular metabolism during low-intensity resistance exercise with blood flow restriction and compared it with that of high-intensity and low-intensity resistance exercises without blood flow restriction using 31P-magnetic resonance spectroscopy. Twenty-six healthy subjects (22 ± 4 yr) participated and performed unilateral plantar flexion (30 repetitions/min) for 2 min. Protocols were as follows: low-intensity exercise (L) using a load of 20% of one-repetition maximum (1 RM), L with blood flow restriction (LR), and high-intensity exercise using 65% 1 RM (H). Intramuscular phosphocreatine (PCr) and diprotonated phosphate (H2PO4-) levels and intramuscular pH at rest and during exercise were obtained. We found that the PCr depletion, the H2PO4- increase, and the intramuscular pH decrease during LR were significantly greater than those in L (P < 0.001); however, those in LR were significantly lower than those in H (P < 0.001). The recruitment of fast-twitch fiber evaluated by inorganic phosphate splitting occurred in only 31% of the subjects in LR, compared with 70% in H. In conclusion, the metabolic stress in skeletal muscle during low-intensity resistance exercise was significantly increased by applying blood flow restriction, but did not generally reach that during high-intensity resistance exercise. This new method of resistance training needs to be examined for optimization of the protocol to reach equivalence with high-intensity resistance training.

Original languageEnglish
Pages (from-to)1119-1124
Number of pages6
JournalJournal of Applied Physiology
Volume106
Issue number4
DOIs
Publication statusPublished - Apr 1 2009

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Exercise
Resistance Training
Phosphocreatine
Phosphates
Physiological Stress
Muscle Strength
Hypertrophy
Healthy Volunteers
Skeletal Muscle
Magnetic Resonance Spectroscopy
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. / Suga, Tadashi; Okita, Koichi; Morita, Noriteru; Yokota, Takashi; Hirabayashi, Kagami; Horiuchi, Masahiro; Takada, Shingo; Takahashi, Tomohiro; Omokawa, Masashi; Kinugawa, Shintaro; Tsutsui, Hiroyuki.

In: Journal of Applied Physiology, Vol. 106, No. 4, 01.04.2009, p. 1119-1124.

Research output: Contribution to journalArticle

Suga, T, Okita, K, Morita, N, Yokota, T, Hirabayashi, K, Horiuchi, M, Takada, S, Takahashi, T, Omokawa, M, Kinugawa, S & Tsutsui, H 2009, 'Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction', Journal of Applied Physiology, vol. 106, no. 4, pp. 1119-1124. https://doi.org/10.1152/japplphysiol.90368.2008
Suga, Tadashi ; Okita, Koichi ; Morita, Noriteru ; Yokota, Takashi ; Hirabayashi, Kagami ; Horiuchi, Masahiro ; Takada, Shingo ; Takahashi, Tomohiro ; Omokawa, Masashi ; Kinugawa, Shintaro ; Tsutsui, Hiroyuki. / Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. In: Journal of Applied Physiology. 2009 ; Vol. 106, No. 4. pp. 1119-1124.
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