Intranasal transportation phenomena of medicinal droplets

T. Yamamoto, S. Nakata, T. Nakashima, T. Yamamoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nebulizer treatment has been used for nasal diseases such as paranasal sinusitis, hypertrophic rhinitis and inferior concha inflammation. The effectiveness of the nebulizer treatment has been confirmed from clinical view points until now. However there are a few researches that evaluate the effect of the nebulizer treatment quantitatively, i.e., how medicinal mist transports and deposits on inflammation areas of nasal wall. Some researchers calculated intranasal transport phenomena of medicinal droplets using Computed Fluid Dynamics (CFD). However these researches analyzed a few cases. The individual difference was left out of consideration even though there were different shapes of nasal cavities and different grade of medical conditions. This study constructs three-dimensional geometry model of nasal cavities using five actual patient's CT data. The cases undergo deviated nasal septum, hypertrophic rhinitis, chronic sinusitis and bloating inferior nasal concha tumentia. This study analyzes the characteristics of airflow and medicinal droplet for the five cases and compared each other to get further knowledge of intranasal phenomena. As a result airflow velocity and pressure drop increase in the narrowing region caused by jet effect. Inlet angle and velocity of nebulizer treatment can easily control medicinal droplet transport characteristics. In the all cases the conditions of inlet angle 25-60 degree give us good treatment condition where medicinal droplet transports wide-area of nasal cavity. Especially this study makes clear circulatory flow is formed in superior concha. The circulatory flow is able to contribute advances medicinal droplet transportation in widespread area of intranasal.

Original languageEnglish
Title of host publication6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Pages729-732
Number of pages4
DOIs
Publication statusPublished - Oct 22 2010
Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore
Duration: Aug 1 2010Aug 6 2010

Publication series

NameIFMBE Proceedings
Volume31 IFMBE
ISSN (Print)1680-0737

Other

Other6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
CountrySingapore
CitySingapore
Period8/1/108/6/10

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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    Yamamoto, T., Nakata, S., Nakashima, T., & Yamamoto, T. (2010). Intranasal transportation phenomena of medicinal droplets. In 6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech (pp. 729-732). (IFMBE Proceedings; Vol. 31 IFMBE). https://doi.org/10.1007/978-3-642-14515-5_186