Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method

Megumu Mori, Toru Chiba, Akira Nakamizo, Ryuichi Kumashiro, Masaharu Murata, Tomohiko Akahoshi, Morimasa Tomikawa, Yuichiro Kikkawa, Koji Yoshimoto, Masahiro Mizoguchi, Tomio Sasaki, Makoto Hashizume

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Superficial temporal artery (STA)—middle cerebral artery (MCA) bypass is an important technique for cerebrovascular reconstruction. Intraoperative hemodynamic imaging is needed to perform cerebrovascular reconstruction safely and effectively. Optical intrinsic signal (OIS) imaging is commonly used for assessing cerebral hemodynamics in experimental studies, because it can provide high-resolution mapping images. However, OIS is not used clinically due to algorithm, instrumentation and spectral resolution limitations. We tested the feasibility of a hyperspectral camera (HSC) for assessment of cortical hemodynamics with spectral imaging of the cerebral cortex in rats and in vivo humans.

Methods: A hyperspectral camera (HSC) was tested in a rat model of cerebral ischemia (middle cerebral artery occlusion) and during human revascularization surgery (STA–MCA anastomosis). Changes in cortical oxygen saturation were derived from spectral imaging data (400–800 nm) collected by exposing the cortex to Xenon light. Reflected light was sampled using the HSC. The system was then tested intraoperatively during superficial temporal artery to middle cerebral artery anastomosis procedures. Comparison with single-photon emission computed tomography (SPECT) imaging data was done.

Results: During middle cerebral artery occlusion in rats, the HSC technique showed a significant decrease in cortical oxygen saturation in the ischemic hemisphere. In clinical cases, the cortical oxygen saturation was increased after STA–MCA anastomosis, which agreed with the SPECT imaging data.

Conclusion: Continuous collection of imaging spectroscopic data is feasible and may provide reliable quantification of the hemodynamic responses in the brain. The HSC system may be useful for monitoring intraoperative changes in cortical surface hemodynamics during revascularization procedures in humans.

Original languageEnglish
Pages (from-to)1059-1072
Number of pages14
JournalInternational Journal of Computer Assisted Radiology and Surgery
Volume9
Issue number6
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Oxygenation
Visualization
Hemodynamics
Imaging techniques
Temporal Arteries
Middle Cerebral Artery Infarction
Middle Cerebral Artery
Cameras
Oxygen
Single-Photon Emission-Computed Tomography
Single photon emission computed tomography
Rats
Intraoperative Monitoring
Light
Xenon
Brain Ischemia
Cerebral Cortex
Spectral resolution
Surgery
Brain

All Science Journal Classification (ASJC) codes

  • Surgery
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design

Cite this

Intraoperative visualization of cerebral oxygenation using hyperspectral image data : a two-dimensional mapping method. / Mori, Megumu; Chiba, Toru; Nakamizo, Akira; Kumashiro, Ryuichi; Murata, Masaharu; Akahoshi, Tomohiko; Tomikawa, Morimasa; Kikkawa, Yuichiro; Yoshimoto, Koji; Mizoguchi, Masahiro; Sasaki, Tomio; Hashizume, Makoto.

In: International Journal of Computer Assisted Radiology and Surgery, Vol. 9, No. 6, 01.01.2014, p. 1059-1072.

Research output: Contribution to journalArticle

Mori, Megumu ; Chiba, Toru ; Nakamizo, Akira ; Kumashiro, Ryuichi ; Murata, Masaharu ; Akahoshi, Tomohiko ; Tomikawa, Morimasa ; Kikkawa, Yuichiro ; Yoshimoto, Koji ; Mizoguchi, Masahiro ; Sasaki, Tomio ; Hashizume, Makoto. / Intraoperative visualization of cerebral oxygenation using hyperspectral image data : a two-dimensional mapping method. In: International Journal of Computer Assisted Radiology and Surgery. 2014 ; Vol. 9, No. 6. pp. 1059-1072.
@article{181fc409fe5144199406d5a0eb538144,
title = "Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method",
abstract = "Purpose: Superficial temporal artery (STA)—middle cerebral artery (MCA) bypass is an important technique for cerebrovascular reconstruction. Intraoperative hemodynamic imaging is needed to perform cerebrovascular reconstruction safely and effectively. Optical intrinsic signal (OIS) imaging is commonly used for assessing cerebral hemodynamics in experimental studies, because it can provide high-resolution mapping images. However, OIS is not used clinically due to algorithm, instrumentation and spectral resolution limitations. We tested the feasibility of a hyperspectral camera (HSC) for assessment of cortical hemodynamics with spectral imaging of the cerebral cortex in rats and in vivo humans.Methods: A hyperspectral camera (HSC) was tested in a rat model of cerebral ischemia (middle cerebral artery occlusion) and during human revascularization surgery (STA–MCA anastomosis). Changes in cortical oxygen saturation were derived from spectral imaging data (400–800 nm) collected by exposing the cortex to Xenon light. Reflected light was sampled using the HSC. The system was then tested intraoperatively during superficial temporal artery to middle cerebral artery anastomosis procedures. Comparison with single-photon emission computed tomography (SPECT) imaging data was done.Results: During middle cerebral artery occlusion in rats, the HSC technique showed a significant decrease in cortical oxygen saturation in the ischemic hemisphere. In clinical cases, the cortical oxygen saturation was increased after STA–MCA anastomosis, which agreed with the SPECT imaging data.Conclusion: Continuous collection of imaging spectroscopic data is feasible and may provide reliable quantification of the hemodynamic responses in the brain. The HSC system may be useful for monitoring intraoperative changes in cortical surface hemodynamics during revascularization procedures in humans.",
author = "Megumu Mori and Toru Chiba and Akira Nakamizo and Ryuichi Kumashiro and Masaharu Murata and Tomohiko Akahoshi and Morimasa Tomikawa and Yuichiro Kikkawa and Koji Yoshimoto and Masahiro Mizoguchi and Tomio Sasaki and Makoto Hashizume",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s11548-014-0989-9",
language = "English",
volume = "9",
pages = "1059--1072",
journal = "Computer-Assisted Radiology and Surgery",
issn = "1861-6410",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Intraoperative visualization of cerebral oxygenation using hyperspectral image data

T2 - a two-dimensional mapping method

AU - Mori, Megumu

AU - Chiba, Toru

AU - Nakamizo, Akira

AU - Kumashiro, Ryuichi

AU - Murata, Masaharu

AU - Akahoshi, Tomohiko

AU - Tomikawa, Morimasa

AU - Kikkawa, Yuichiro

AU - Yoshimoto, Koji

AU - Mizoguchi, Masahiro

AU - Sasaki, Tomio

AU - Hashizume, Makoto

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: Superficial temporal artery (STA)—middle cerebral artery (MCA) bypass is an important technique for cerebrovascular reconstruction. Intraoperative hemodynamic imaging is needed to perform cerebrovascular reconstruction safely and effectively. Optical intrinsic signal (OIS) imaging is commonly used for assessing cerebral hemodynamics in experimental studies, because it can provide high-resolution mapping images. However, OIS is not used clinically due to algorithm, instrumentation and spectral resolution limitations. We tested the feasibility of a hyperspectral camera (HSC) for assessment of cortical hemodynamics with spectral imaging of the cerebral cortex in rats and in vivo humans.Methods: A hyperspectral camera (HSC) was tested in a rat model of cerebral ischemia (middle cerebral artery occlusion) and during human revascularization surgery (STA–MCA anastomosis). Changes in cortical oxygen saturation were derived from spectral imaging data (400–800 nm) collected by exposing the cortex to Xenon light. Reflected light was sampled using the HSC. The system was then tested intraoperatively during superficial temporal artery to middle cerebral artery anastomosis procedures. Comparison with single-photon emission computed tomography (SPECT) imaging data was done.Results: During middle cerebral artery occlusion in rats, the HSC technique showed a significant decrease in cortical oxygen saturation in the ischemic hemisphere. In clinical cases, the cortical oxygen saturation was increased after STA–MCA anastomosis, which agreed with the SPECT imaging data.Conclusion: Continuous collection of imaging spectroscopic data is feasible and may provide reliable quantification of the hemodynamic responses in the brain. The HSC system may be useful for monitoring intraoperative changes in cortical surface hemodynamics during revascularization procedures in humans.

AB - Purpose: Superficial temporal artery (STA)—middle cerebral artery (MCA) bypass is an important technique for cerebrovascular reconstruction. Intraoperative hemodynamic imaging is needed to perform cerebrovascular reconstruction safely and effectively. Optical intrinsic signal (OIS) imaging is commonly used for assessing cerebral hemodynamics in experimental studies, because it can provide high-resolution mapping images. However, OIS is not used clinically due to algorithm, instrumentation and spectral resolution limitations. We tested the feasibility of a hyperspectral camera (HSC) for assessment of cortical hemodynamics with spectral imaging of the cerebral cortex in rats and in vivo humans.Methods: A hyperspectral camera (HSC) was tested in a rat model of cerebral ischemia (middle cerebral artery occlusion) and during human revascularization surgery (STA–MCA anastomosis). Changes in cortical oxygen saturation were derived from spectral imaging data (400–800 nm) collected by exposing the cortex to Xenon light. Reflected light was sampled using the HSC. The system was then tested intraoperatively during superficial temporal artery to middle cerebral artery anastomosis procedures. Comparison with single-photon emission computed tomography (SPECT) imaging data was done.Results: During middle cerebral artery occlusion in rats, the HSC technique showed a significant decrease in cortical oxygen saturation in the ischemic hemisphere. In clinical cases, the cortical oxygen saturation was increased after STA–MCA anastomosis, which agreed with the SPECT imaging data.Conclusion: Continuous collection of imaging spectroscopic data is feasible and may provide reliable quantification of the hemodynamic responses in the brain. The HSC system may be useful for monitoring intraoperative changes in cortical surface hemodynamics during revascularization procedures in humans.

UR - http://www.scopus.com/inward/record.url?scp=84939879736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939879736&partnerID=8YFLogxK

U2 - 10.1007/s11548-014-0989-9

DO - 10.1007/s11548-014-0989-9

M3 - Article

C2 - 24737109

AN - SCOPUS:84939879736

VL - 9

SP - 1059

EP - 1072

JO - Computer-Assisted Radiology and Surgery

JF - Computer-Assisted Radiology and Surgery

SN - 1861-6410

IS - 6

ER -