Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease

S. Ohga, K. Ikeuchi, R. Kadoya, K. Okada, C. Miyazaki, S. Suita, K. Ueda

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O2- release and expression of NADPH oxidase components verified that he suffered from gp91-phox- chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalJournal of Infection
Volume34
Issue number2
DOIs
Publication statusPublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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