Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease

Shoichi Ohga, K. Ikeuchi, R. Kadoya, K. Okada, C. Miyazaki, S. Suita, K. Ueda

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O 2 - release and expression of NADPH oxidase components verified that he suffered from gp91-phox - chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalJournal of Infection
Volume34
Issue number2
DOIs
Publication statusPublished - Jan 1 1997

Fingerprint

Chronic Granulomatous Disease
Mycobacterium avium
Mycobacterium Infections
NADPH Oxidase
antineoplaston A10
Mediastinum
Phagocytes
Infection
Granuloma
Fever
Necrosis
Mothers
Biopsy
Lung

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease. / Ohga, Shoichi; Ikeuchi, K.; Kadoya, R.; Okada, K.; Miyazaki, C.; Suita, S.; Ueda, K.

In: Journal of Infection, Vol. 34, No. 2, 01.01.1997, p. 147-150.

Research output: Contribution to journalArticle

Ohga, Shoichi ; Ikeuchi, K. ; Kadoya, R. ; Okada, K. ; Miyazaki, C. ; Suita, S. ; Ueda, K. / Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease. In: Journal of Infection. 1997 ; Vol. 34, No. 2. pp. 147-150.
@article{43dc94df8f72435a91112851936adb3f,
title = "Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease",
abstract = "A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O 2 - release and expression of NADPH oxidase components verified that he suffered from gp91-phox - chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.",
author = "Shoichi Ohga and K. Ikeuchi and R. Kadoya and K. Okada and C. Miyazaki and S. Suita and K. Ueda",
year = "1997",
month = "1",
day = "1",
doi = "10.1016/S0163-4453(97)92509-3",
language = "English",
volume = "34",
pages = "147--150",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease

AU - Ohga, Shoichi

AU - Ikeuchi, K.

AU - Kadoya, R.

AU - Okada, K.

AU - Miyazaki, C.

AU - Suita, S.

AU - Ueda, K.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O 2 - release and expression of NADPH oxidase components verified that he suffered from gp91-phox - chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.

AB - A 10-month-old Japanese male infant, with no history of being prone to infections, contracted an intrapulmonary mycobacterial infection. After 2 months of intermittent fever, radiological examinations revealed mass lesions in the lung and mediastinum. Biopsy specimens showed granulomas with caseous necrosis, from which Mycobacterium avium was isolated. There was no history of mycobacteriosis or immunodeficiency diseases among his relatives. Analyses of the O 2 - release and expression of NADPH oxidase components verified that he suffered from gp91-phox - chronic granulomatous disease (CGD), and that his mother was a carrier of the disease. This is a rare clinical presentation for the onset of CGD, suggesting that the invasive mycobacteriosis might result from defective intracellular killing of CGD-phagocytes.

UR - http://www.scopus.com/inward/record.url?scp=0030934530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030934530&partnerID=8YFLogxK

U2 - 10.1016/S0163-4453(97)92509-3

DO - 10.1016/S0163-4453(97)92509-3

M3 - Article

C2 - 9138139

AN - SCOPUS:0030934530

VL - 34

SP - 147

EP - 150

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 2

ER -