Intratumor heterogeneity of HMCN1 mutant alleles associated with poor prognosis in patients with breast cancer

Chie Kikutake, Minako Yoshihara, Tetsuya Sato, Daisuke Saito, Mikita Suyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Human breast cancers comprise a complex and highly heterogeneous population of tumor cells. Intratumor heterogeneity is an underlying cause of resistance to effective therapies and disease recurrence. To explore prognostic factors based on intratumor heterogeneity, we analyzed genomic mutations in breast cancer patients registered in The Cancer Genome Atlas. We calculated the variant allele frequency (VAF) at each mutation site and evaluated the associations of VAFs with the prognosis of breast cancer. VAFs of HMCN1 correlated with the prognosis and lymph node status. Although the detailed function of HMCN1 remains unknown, it is located in extracellular matrix and the mutation in the gene might be associated with cancer cell invasion and metastasis. This finding suggests that HMCN1 is a potential metastatic factor and can be a candidate gene for targeted breast cancer therapy.

Original languageEnglish
Pages (from-to)33337-33347
Number of pages11
JournalOncotarget
Volume9
Issue number70
DOIs
Publication statusPublished - Sep 1 2018

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All Science Journal Classification (ASJC) codes

  • Oncology

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