Intratumoral expression of macrophage migration inhibitory factor is correlated with serum C-reactive protein and interleukin-6 in patients with non-small cell lung cancer

Motoharu Hamatake, Ichiro Yoshino, Makiko Tomiyasu, Naoko Miura, Hiroshi Okazaki, Taro Oba, Tomohiro Takenaka, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Purpose. To investigate if macrophage migration inhibitory factor (MIF) affects systemic inflammatory response in patients with non-small cell lung cancer (NSCLC), we studied the relationship between intratumoral MIF expression and serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6). Methods. mRNAs for MIF and β-actin, and 18S ribosomal RNA derived from tumor-bearing and nontumor-bearing tissues were quantified by a quantitative reverse transcription-polymerase chain reaction in 35 patients with NSCLC. Spearman's test was used to examine the correlation between the quantities of RNAs and the preoperative serum levels of CRP and IL-6 in the corresponding patients. Results. The intratumoral level of MIF mRNA was significantly correlated with the serum levels of CRP (ρ = 0.542, P = 0.0016) and IL-6 (ρ = 0.532, P = 0.0173). The level of MIF mRNA in the non-tumor-bearing lung also showed a positive, but relatively weak correlation with the serum CRP level (ρ = 0.418, P = 0.0148). Conclusion. Macrophage migration inhibitory factor expression in the tumor site may affect the systemic inflammatory response in patients with NSCLC.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalSurgery Today
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 2008

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Macrophage Migration-Inhibitory Factors
Non-Small Cell Lung Carcinoma
C-Reactive Protein
Blood Proteins
Interleukin-6
Messenger RNA
18S Ribosomal RNA
Serum
Reverse Transcription
Actins
Neoplasms
RNA
Polymerase Chain Reaction
Lung

All Science Journal Classification (ASJC) codes

  • Surgery

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Intratumoral expression of macrophage migration inhibitory factor is correlated with serum C-reactive protein and interleukin-6 in patients with non-small cell lung cancer. / Hamatake, Motoharu; Yoshino, Ichiro; Tomiyasu, Makiko; Miura, Naoko; Okazaki, Hiroshi; Oba, Taro; Takenaka, Tomohiro; Maehara, Yoshihiko.

In: Surgery Today, Vol. 38, No. 10, 10.2008, p. 921-925.

Research output: Contribution to journalArticle

Hamatake, Motoharu ; Yoshino, Ichiro ; Tomiyasu, Makiko ; Miura, Naoko ; Okazaki, Hiroshi ; Oba, Taro ; Takenaka, Tomohiro ; Maehara, Yoshihiko. / Intratumoral expression of macrophage migration inhibitory factor is correlated with serum C-reactive protein and interleukin-6 in patients with non-small cell lung cancer. In: Surgery Today. 2008 ; Vol. 38, No. 10. pp. 921-925.
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abstract = "Purpose. To investigate if macrophage migration inhibitory factor (MIF) affects systemic inflammatory response in patients with non-small cell lung cancer (NSCLC), we studied the relationship between intratumoral MIF expression and serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6). Methods. mRNAs for MIF and β-actin, and 18S ribosomal RNA derived from tumor-bearing and nontumor-bearing tissues were quantified by a quantitative reverse transcription-polymerase chain reaction in 35 patients with NSCLC. Spearman's test was used to examine the correlation between the quantities of RNAs and the preoperative serum levels of CRP and IL-6 in the corresponding patients. Results. The intratumoral level of MIF mRNA was significantly correlated with the serum levels of CRP (ρ = 0.542, P = 0.0016) and IL-6 (ρ = 0.532, P = 0.0173). The level of MIF mRNA in the non-tumor-bearing lung also showed a positive, but relatively weak correlation with the serum CRP level (ρ = 0.418, P = 0.0148). Conclusion. Macrophage migration inhibitory factor expression in the tumor site may affect the systemic inflammatory response in patients with NSCLC.",
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AU - Miura, Naoko

AU - Okazaki, Hiroshi

AU - Oba, Taro

AU - Takenaka, Tomohiro

AU - Maehara, Yoshihiko

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