Abstract
Previously, we have shown that CD8+T/FOXP3+ cell ratio but not FOXP3+ cell number alone is an independent prognostic factor for colorectal cancer. In the present study, we evaluated whether the number of intratumoral FOXP3+VEGFR2+ (itFOXP3+VEGFR2+) T cells alone could be a predictive factor for survival prognosis in patients with colorectal cancer. Distribution of regulatory T cells (Tregs) at tumor sites derived from 88 patients with primary colorectal cancer was fluorescence-immunohistochemically examined. Relatively low number of itFOXP3+VEGFR2+ cells significantly correlated with poor disease-free survival (DS) and overall survival (OS); multivariate analysis indicated that number of itFOXP3+VEGFR2+ cells is an independent predictive and prognostic factor of DS and OS while neither intratumoral FOXP3+ cell number nor intratumoral FOXP3+VEGFR2- cell number alone showed significant correlation with DS or OS. These results suggest that FOXP3+VEGFR2+ may be a better predictive Treg marker than FOXP3+ alone for recurrence and survival in patients with colorectal cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 26-33 |
| Number of pages | 8 |
| Journal | Clinical Immunology |
| Volume | 146 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2013 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer. / Suzuki, Hiroyuki; Onishi, Hideya; Morisaki, Takashi; Tanaka, Masao; Katano, Mitsuo.
In: Clinical Immunology, Vol. 146, No. 1, 01.01.2013, p. 26-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer
AU - Suzuki, Hiroyuki
AU - Onishi, Hideya
AU - Morisaki, Takashi
AU - Tanaka, Masao
AU - Katano, Mitsuo
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Previously, we have shown that CD8+T/FOXP3+ cell ratio but not FOXP3+ cell number alone is an independent prognostic factor for colorectal cancer. In the present study, we evaluated whether the number of intratumoral FOXP3+VEGFR2+ (itFOXP3+VEGFR2+) T cells alone could be a predictive factor for survival prognosis in patients with colorectal cancer. Distribution of regulatory T cells (Tregs) at tumor sites derived from 88 patients with primary colorectal cancer was fluorescence-immunohistochemically examined. Relatively low number of itFOXP3+VEGFR2+ cells significantly correlated with poor disease-free survival (DS) and overall survival (OS); multivariate analysis indicated that number of itFOXP3+VEGFR2+ cells is an independent predictive and prognostic factor of DS and OS while neither intratumoral FOXP3+ cell number nor intratumoral FOXP3+VEGFR2- cell number alone showed significant correlation with DS or OS. These results suggest that FOXP3+VEGFR2+ may be a better predictive Treg marker than FOXP3+ alone for recurrence and survival in patients with colorectal cancer.
AB - Previously, we have shown that CD8+T/FOXP3+ cell ratio but not FOXP3+ cell number alone is an independent prognostic factor for colorectal cancer. In the present study, we evaluated whether the number of intratumoral FOXP3+VEGFR2+ (itFOXP3+VEGFR2+) T cells alone could be a predictive factor for survival prognosis in patients with colorectal cancer. Distribution of regulatory T cells (Tregs) at tumor sites derived from 88 patients with primary colorectal cancer was fluorescence-immunohistochemically examined. Relatively low number of itFOXP3+VEGFR2+ cells significantly correlated with poor disease-free survival (DS) and overall survival (OS); multivariate analysis indicated that number of itFOXP3+VEGFR2+ cells is an independent predictive and prognostic factor of DS and OS while neither intratumoral FOXP3+ cell number nor intratumoral FOXP3+VEGFR2- cell number alone showed significant correlation with DS or OS. These results suggest that FOXP3+VEGFR2+ may be a better predictive Treg marker than FOXP3+ alone for recurrence and survival in patients with colorectal cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=84870375752&partnerID=8YFLogxK
U2 - 10.1016/j.clim.2012.10.007
DO - 10.1016/j.clim.2012.10.007
M3 - Article
C2 - 23202541
AN - SCOPUS:84870375752
VL - 146
SP - 26
EP - 33
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -