Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer

Hiroyuki Suzuki, Hideya Onishi, Takashi Morisaki, Masao Tanaka, Mitsuo Katano

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Previously, we have shown that CD8+T/FOXP3+ cell ratio but not FOXP3+ cell number alone is an independent prognostic factor for colorectal cancer. In the present study, we evaluated whether the number of intratumoral FOXP3+VEGFR2+ (itFOXP3+VEGFR2+) T cells alone could be a predictive factor for survival prognosis in patients with colorectal cancer. Distribution of regulatory T cells (Tregs) at tumor sites derived from 88 patients with primary colorectal cancer was fluorescence-immunohistochemically examined. Relatively low number of itFOXP3+VEGFR2+ cells significantly correlated with poor disease-free survival (DS) and overall survival (OS); multivariate analysis indicated that number of itFOXP3+VEGFR2+ cells is an independent predictive and prognostic factor of DS and OS while neither intratumoral FOXP3+ cell number nor intratumoral FOXP3+VEGFR2- cell number alone showed significant correlation with DS or OS. These results suggest that FOXP3+VEGFR2+ may be a better predictive Treg marker than FOXP3+ alone for recurrence and survival in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalClinical Immunology
Volume146
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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