Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer

Hiroyuki Suzuki, Hideya Ohnishi, Takashi Morisaki, Masao Tanaka, Mitsuo Katano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Previously, we have shown that CD8+T/FOXP3+ cell ratio but not FOXP3+ cell number alone is an independent prognostic factor for colorectal cancer. In the present study, we evaluated whether the number of intratumoral FOXP3+VEGFR2+ (itFOXP3+VEGFR2+) T cells alone could be a predictive factor for survival prognosis in patients with colorectal cancer. Distribution of regulatory T cells (Tregs) at tumor sites derived from 88 patients with primary colorectal cancer was fluorescence-immunohistochemically examined. Relatively low number of itFOXP3+VEGFR2+ cells significantly correlated with poor disease-free survival (DS) and overall survival (OS); multivariate analysis indicated that number of itFOXP3+VEGFR2+ cells is an independent predictive and prognostic factor of DS and OS while neither intratumoral FOXP3+ cell number nor intratumoral FOXP3+VEGFR2- cell number alone showed significant correlation with DS or OS. These results suggest that FOXP3+VEGFR2+ may be a better predictive Treg marker than FOXP3+ alone for recurrence and survival in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalClinical Immunology
Volume146
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

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Regulatory T-Lymphocytes
Colorectal Neoplasms
Recurrence
Survival
Disease-Free Survival
Cell Count
Multivariate Analysis
Fluorescence
T-Lymphocytes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer. / Suzuki, Hiroyuki; Ohnishi, Hideya; Morisaki, Takashi; Tanaka, Masao; Katano, Mitsuo.

In: Clinical Immunology, Vol. 146, No. 1, 01.01.2013, p. 26-33.

Research output: Contribution to journalArticle

Suzuki, Hiroyuki ; Ohnishi, Hideya ; Morisaki, Takashi ; Tanaka, Masao ; Katano, Mitsuo. / Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer. In: Clinical Immunology. 2013 ; Vol. 146, No. 1. pp. 26-33.
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