Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer

Keisuke Ikeda, Eiji Oki, Hiroshi Saeki, Kouji Andou, Masaru Morita, Yoshinao Oda, Masakazu Imamura, Yoshiniro Kakeji, Yoshihiko Maehara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aim: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various human cancer tissues. Materials and Methods: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. Results: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). Conclusion: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value.

Original languageEnglish
Pages (from-to)3911-3916
Number of pages6
JournalAnticancer research
Volume34
Issue number8
Publication statusPublished - Aug 1 2014

Fingerprint

Lymphangiogenesis
Vascular Endothelial Growth Factor C
Stomach Neoplasms
Lymphatic Vessels
Neoplasm Metastasis
Neoplasms
Lymph
Lymph Nodes
Monoclonal Antibodies
Staining and Labeling
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer. / Ikeda, Keisuke; Oki, Eiji; Saeki, Hiroshi; Andou, Kouji; Morita, Masaru; Oda, Yoshinao; Imamura, Masakazu; Kakeji, Yoshiniro; Maehara, Yoshihiko.

In: Anticancer research, Vol. 34, No. 8, 01.08.2014, p. 3911-3916.

Research output: Contribution to journalArticle

Ikeda, K, Oki, E, Saeki, H, Andou, K, Morita, M, Oda, Y, Imamura, M, Kakeji, Y & Maehara, Y 2014, 'Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer', Anticancer research, vol. 34, no. 8, pp. 3911-3916.
Ikeda, Keisuke ; Oki, Eiji ; Saeki, Hiroshi ; Andou, Kouji ; Morita, Masaru ; Oda, Yoshinao ; Imamura, Masakazu ; Kakeji, Yoshiniro ; Maehara, Yoshihiko. / Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer. In: Anticancer research. 2014 ; Vol. 34, No. 8. pp. 3911-3916.
@article{c8796e36d8c74f40b00d4dc8fd4707e6,
title = "Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer",
abstract = "Aim: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various human cancer tissues. Materials and Methods: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. Results: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). Conclusion: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value.",
author = "Keisuke Ikeda and Eiji Oki and Hiroshi Saeki and Kouji Andou and Masaru Morita and Yoshinao Oda and Masakazu Imamura and Yoshiniro Kakeji and Yoshihiko Maehara",
year = "2014",
month = "8",
day = "1",
language = "English",
volume = "34",
pages = "3911--3916",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "8",

}

TY - JOUR

T1 - Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer

AU - Ikeda, Keisuke

AU - Oki, Eiji

AU - Saeki, Hiroshi

AU - Andou, Kouji

AU - Morita, Masaru

AU - Oda, Yoshinao

AU - Imamura, Masakazu

AU - Kakeji, Yoshiniro

AU - Maehara, Yoshihiko

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Aim: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various human cancer tissues. Materials and Methods: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. Results: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). Conclusion: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value.

AB - Aim: Vascular endothelial growth factor C (VEGFC) is thought to promote lymphangiogenesis in various human cancer tissues. Materials and Methods: The present study analyzed data from 72 patients with gastric cancer. The lymphatic vessel density (LVD) was determined by immunohistochemical staining using a monoclonal antibody (mAb) against D2-40, and the expression of VEGFC was investigated using a mAb against VEGFC. Results: The intratumoral LVD was higher in cases with nodal metastasis. The VEGFC-positive cases had a higher intratumoral LVD and were more invasive to the lymphatic vessels or lymph nodes than negative cases. Patients with VEGFC-positive cancer had significantly lower survival than those with negative cancer (p<0.05). Conclusion: The expression of VEGFC was related to intratumoral lymph angiogenesis and serves as a pertinent predictive factor for lymphatic invasion or metastasis, while also providing prognostic value.

UR - http://www.scopus.com/inward/record.url?scp=84908698884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908698884&partnerID=8YFLogxK

M3 - Article

C2 - 25075012

AN - SCOPUS:84908698884

VL - 34

SP - 3911

EP - 3916

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 8

ER -