Intravascular lymphoma confirmed by brain biopsy, quickly treated by chemotherapy: A case report

Daisuke Inoue, Takeshi Hamamura, Taira Uehara, Katsue Miyoshi, Takefumi Katsuragi, Iwao Takeshita, Tetsuo Hamada

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Abstract

A 60-year-old female with intravascular lymphoma (IVU presented with the complaint of urinary dysfunction and gait disturbance. T2 weighted MR imaging of the thoracic spinal cord showed a hyperintense lesion, and brain MR imaging indicated hyperintense lesions in the deep white matter. Multiple sclerosis was assumed, so steroid pulse therapy was administered. However, her level of consciousness decreased and her paraplegia progressed. Laboratory data showed that anemia and thrombocytopenia had worsened with high serum LDH and soluble (L-2 receptor levels. Biopsy of bone marrow indicated rryperceHularity associated with hemophagocytic histiocytes, although no atypical lymphocytes were detected. Sraln MR imaging Indicated a new subcortical lesion in the left parietal lobe. One and a half months after admission, an open brain biopsy of the left parietal cortex was performed. Hlstopathological diagnosis was IVL, large B cell type. Immediately, she underwent CHOP therapy containing rituximab (R-CHOP therapy). After chemotherapy, spinal and brain MR Images showed no new abnormal lesions. Clinically, It Is difficult to make a diagnosis of IVL in life as It has no characteristic symptoms or radiological findings. Therefore, if a patient is suspected of having IVL, a biopsy of different organs, including brain, is necessary for making an early diagnosis and Initiating chemotherapy.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalNeurological Surgery
Volume37
Issue number4
Publication statusPublished - Apr 1 2009

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Inoue, D., Hamamura, T., Uehara, T., Miyoshi, K., Katsuragi, T., Takeshita, I., & Hamada, T. (2009). Intravascular lymphoma confirmed by brain biopsy, quickly treated by chemotherapy: A case report. Neurological Surgery, 37(4), 369-374.