Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection

Eiichi Ogawa, Shigeru Otaguro, Murata Masayuki, Mosaburo Kainuma, Yasunori Sawayama, Norihiro Furusyo, Jun Hayashi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Symptoms caused by acute human parvovirus B19 (HPV-B19) infection can vary considerably, from asymptomatic to severely symptomatic. A 39-year-old Japanese woman complained of sudden, severe arthralgia with edematous limbs coincident with an outbreak of HPV-B19 infection at the elementary school attended by her daughter. A diagnosis of acute HPV-B19 infection was made by the detection of serum antibody to HPV-B19 IgM and HPV-B19 DNA. Magnetic resonance imaging revealed bilateral synovitis of the cubital joints. The patient was immunocompetent and suffered from severe arthralgia associated with persistent HPV-B19 viremia for more than 4 months after the diagnosis of acute HPV-B19 infection. The administration of high-dose intravenous immunoglobulin resulted in remission, with little change in the serum HPV-B19 DNA level. Even in our immunocompetent patient, severe and prolonged arthritis was found to be associated with persistent viremia.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume14
Issue number5
DOIs
Publication statusPublished - Jan 1 2008

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Human Parvovirus B19
Parvoviridae Infections
Passive Immunization
Intravenous Immunoglobulins
Arthritis
Viremia
Arthralgia
Synovitis
DNA
Serum
Nuclear Family
Disease Outbreaks
Immunoglobulin M
Extremities
Joints
Magnetic Resonance Imaging
Antibodies

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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Intravenous immunoglobulin therapy for severe arthritis associated with human parvovirus B19 infection. / Ogawa, Eiichi; Otaguro, Shigeru; Masayuki, Murata; Kainuma, Mosaburo; Sawayama, Yasunori; Furusyo, Norihiro; Hayashi, Jun.

In: Journal of Infection and Chemotherapy, Vol. 14, No. 5, 01.01.2008, p. 377-382.

Research output: Contribution to journalArticle

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