Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: A case report

Ryuji Uehara; Koji Yamashita; Akio Hiwatashi; Osamu Togao; Kazufumi Kikuchi; Jun Yokoyama; Dai Matsuse; Takashi Yoshiura; Hiroshi Honda

doi:10.1002/brb3.282

Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: A case report

Ryuji Uehara, Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Jun Yokoyama, Dai Matsuse, Takashi Yoshiura, Hiroshi Honda

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase. Results: On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas. Conclusion: These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.

Original language	English
Pages (from-to)	798-800
Number of pages	3
Journal	Brain and Behavior
Volume	4
Issue number	6
DOIs	https://doi.org/10.1002/brb3.282
Publication status	Published - Nov 1 2014

All Science Journal Classification (ASJC) codes

Behavioral Neuroscience

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10.1002/brb3.282

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Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS : A case report. / Uehara, Ryuji; Yamashita, Koji; Hiwatashi, Akio; Togao, Osamu ; Kikuchi, Kazufumi; Yokoyama, Jun; Matsuse, Dai; Yoshiura, Takashi; Honda, Hiroshi.

In: Brain and Behavior, Vol. 4, No. 6, 01.11.2014, p. 798-800.

Research output: Contribution to journal › Article › peer-review

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abstract = "Objective: We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase. Results: On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas. Conclusion: These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.",

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AU - Togao, Osamu

AU - Kikuchi, Kazufumi

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AU - Matsuse, Dai

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AU - Honda, Hiroshi

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Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: A case report

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